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Mapping the colorectal tumor microbiota.
Murphy, C L; Barrett, M; Pellanda, P; Killeen, S; McCourt, M; Andrews, E; O' Riordain, M; Shanahan, F; O'Toole, Pw.
Afiliación
  • Murphy CL; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland.
  • Barrett M; Departments of Gastroenterology and Medicine, Cork University Hospital, Cork, Ireland.
  • Pellanda P; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland.
  • Killeen S; School of Microbiology, University College Cork, National University of Ireland Cork, Ireland.
  • McCourt M; APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland.
  • Andrews E; School of Microbiology, University College Cork, National University of Ireland Cork, Ireland.
  • O' Riordain M; Department of Colorectal Surgery, Mercy University Hospital, Cork, Ireland.
  • Shanahan F; Department of Colorectal Surgery, Cork University Hospital, Cork, Ireland.
  • O'Toole P; Department of Colorectal Surgery, Cork University Hospital, Cork, Ireland.
Gut Microbes ; 13(1): 1-10, 2021.
Article en En | MEDLINE | ID: mdl-34030582
The gut microbiome in patients with colorectal cancer (CRC) is different than that of healthy controls. Previous studies have profiled the CRC tumor microbiome using a single biopsy. However, since the morphology and cellular subtype vary significantly within an individual tumor, the possibility of sampling error arises for the microbiome within an individual tumor. To test this hypothesis, seven biopsies were taken from representative areas on and off the tumor in five patients with CRC. The microbiome composition was strikingly similar across all samples from an individual. The variation in microbiome alpha-diversity was significantly greater between individuals' samples then within individuals. This is the first study, to our knowledge, that shows that the microbiome of an individual tumor is spatially homogeneous. Our finding strengthens the assumption that a single biopsy is representative of the entire tumor, and that microbiota changes are not limited to a specific area of the neoplasm.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Neoplasias Colorrectales / Microbioma Gastrointestinal Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Microbes Año: 2021 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Neoplasias Colorrectales / Microbioma Gastrointestinal Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Microbes Año: 2021 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos