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In vitro examination of anti-parasitic, anti-Alzheimer, insecticidal and cytotoxic potential of Ajuga bracteosa Wallich leaves extracts.
Imran, Muhammad; Jan, Hasnain; Faisal, Shah; Ali Shah, Sajjad; Shah, Sumaira; Naeem Khan, Muhammad; Taj Akbar, Muhammad; Rizwan, Muhammad; Jan, Faheem; Syed, Suliman.
Afiliación
  • Imran M; Department of Botany, Government Post Graduate College Charsadda, KPK, Pakistan.
  • Jan H; Department of Botany, Islamia College Peshawar, KPK, Pakistan.
  • Faisal S; Department of Biotechnology, Quaid-i-Azam University 45320, Islamabad, Pakistan.
  • Ali Shah S; Department of Biotechnology, Bacha Khan University, Charsadda, KPK, Pakistan.
  • Shah S; Department of Biotechnology, Bacha Khan University, Charsadda, KPK, Pakistan.
  • Naeem Khan M; Department of Botany, Bacha Khan University Charsadda, KPK, Pakistan.
  • Taj Akbar M; Department of Botany, Government Post Graduate College Charsadda, KPK, Pakistan.
  • Rizwan M; Department of Biotechnology and Genetic Engineering, Agriculture University KPK, Pakistan.
  • Jan F; Department of Microbiology, Abdul Wali Khan University, Mardan, KPK, Pakistan.
  • Syed S; Center for Biotechnology and Microbiology University of Swat, KPK, Pakistan.
Saudi J Biol Sci ; 28(5): 3031-3036, 2021 May.
Article en En | MEDLINE | ID: mdl-34025179
This research study is mainly focused to evaluate the anti-parasitic, insecticidal, cytotoxic and anti-alzheimer potential of various leaf extracts of Ajuga bracteosa Wallich ex Bentham. 04 different extracts were prepared using solvent of different polarity to determine the best candidate for potent bioactivity i.e. n-hexane (NH), Ethyl acetate (EA), Ethanol (EL) and Chloroform (CH). Concentrations of each extracts were made specified for all activities. All extracts were exploited for broad range of biomedical applications including leishmaniasis, in vitro anti-Alzheimer, insecticidal and cytotoxic studies. Our results showed that A. bracteosa n-hexane extract was highly active against Leishmania Tropica with significant inhibition of 58 ± 1.61 for promastigote and 63 ± 2.29 for amastigote at 1000 µg/mL. Furthermore, promising anti-alzheimer activity acetylcholinesterase (AChE) 46 ± 0.83 and butrylcholineterase (BChE) 49 ± 1.17 was noted for n-hexane. The insecticidal potential of these extracts were test against five different insects (Rhyzopertha dominica, Trogoderma granarium, Tribolium castaneum, Sitophilus oryze, and Callosobruchus analis). The higest mortality rate of insecticidal activity was recorded by n-hexane followed by Ethyl acetate whereas ethanol extract was found to be less effective against all the test species. Significant cytotoxic potential of each plant sample against Artemia salina thus aware us for further detailed research to find out novel drugs. Based on our results we believe that Ajuga bracteosa could be used to develop as a potential botanical insecticide against different insect and pests, such as aphids as well as an excellent source for the compound isolation as anti-tumor agent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Saudi J Biol Sci Año: 2021 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Arabia Saudita
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Saudi J Biol Sci Año: 2021 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Arabia Saudita