Saponins from <i>Panax japonicus</i> ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-&#954;B and TGF-ß1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling.

Gao, Yan; Yuan, Ding; Gai, Liyue; Wu, Xuelian; Shi, Yue; He, Yumin; Liu, Chaoqi; Zhang, Changcheng; Zhou, Gang; Yuan, Chengfu

Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-ß1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling.

Gao, Yan; Yuan, Ding; Gai, Liyue; Wu, Xuelian; Shi, Yue; He, Yumin; Liu, Chaoqi; Zhang, Changcheng; Zhou, Gang; Yuan, Chengfu.

Afiliación

Gao Y; College of Medical Science, China Three Gorges University, Yichang, China.
Yuan D; College of Medical Science, China Three Gorges University, Yichang, China.
Gai L; College of Medical Science, China Three Gorges University, Yichang, China.
Wu X; College of Medical Science, China Three Gorges University, Yichang, China.
Shi Y; College of Medical Science, China Three Gorges University, Yichang, China.
He Y; College of Medical Science, China Three Gorges University, Yichang, China.
Liu C; College of Medical Science, China Three Gorges University, Yichang, China.
Zhang C; College of Medical Science, China Three Gorges University, Yichang, China.
Zhou G; College of Traditional Chinese Medicine, China Three Gorges University, Yichang, China.
Yuan C; College of Medical Science, China Three Gorges University, Yichang, China.

J Ginseng Res ; 45(3): 408-419, 2021 May.

Article en En | MEDLINE | ID: mdl-34025134

Palabras clave

ARE, antioxidant response element; Aging; COX2, cyclooxygenase-2; Cys C, cystatin C; ECM, extracellular matrix; HO-1, human heme oxygenase 1; IL-6, interleukin-6; IκB, inhibitor of NF-κB; LPO, lipid peroxides; MCP-1, monocyte chemoattractant protein-1; MMPs, matrix metalloproteinases; NF-κB, nuclear factor kappa-B; NQO1, recombinant NADH dehydrogenase quinone 1; Nrf2, nuclear factor erythroid 2-related factor 2; Nrf2-ARE signaling pathways; PJ, Panax japonicas; Renal fibrosis; SD, Sprague-Dawley; SPJ-H, high-dose of SPJ; SPJ-L, low-dose of SPJ; SPJs, saponins from panax japonicus; TGF-ß1, tumor growth factor-ß1; TGF-ß1/Smad; TIMPs, tissue inhibitors of metalloproteinases; TNF-α, tumor necrosis factor-α; Total saponins of panax japonicus; UA, uric acid; α-SMA, α-smooth muscle aorta; ß2-MG, ß2-microglobulin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Ginseng Res Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación:

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