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Biophysical properties of corneal cells reflect high myopia progression.
Xin, Ying; Kang, Byung Soo; Zheng, Yong-Ping; Shan, Sze Wan; Kee, Chea-Su; Tan, Youhua.
Afiliación
  • Xin Y; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
  • Kang BS; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
  • Zheng YP; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
  • Shan SW; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
  • Kee CS; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address: c.kee@polyu.edu.hk.
  • Tan Y; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address: youhua.tan@polyu.edu.hk.
Biophys J ; 120(16): 3498-3507, 2021 08 17.
Article en En | MEDLINE | ID: mdl-34022236
Myopia is a common ocular disorder with significant alterations in the anterior ocular structure, including the cornea. The cell biophysical phenotype has been proposed to reflect the state of various diseases. However, the biophysical properties of corneal cells have not been characterized during myopia progression and their relationship with myopia remains unknown. This study characterizes the biophysical properties of corneal cells in normal, myopic, and recovered conditions, using two classical myopia models. Surprisingly, myopic corneal cells considerably reduce F-actin and microtubule content and cellular stiffness and generate elevated traction force compared with control cells. When myopia is restored to the healthy state, these biophysical properties are partially or fully restored to the levels of control cells. Furthermore, the level of chromatin condensation is significantly increased in the nucleus of myopic corneal cells and reduced to a level similar to healthy cells after recovery. These findings demonstrate that the reversible biophysical alterations of corneal cells reflect myopia progression, facilitating the study of the role of corneal cell biophysics in myopia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miopía Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biophys J Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Miopía Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biophys J Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos