Your browser doesn't support javascript.
loading
A flexible multiplexed immunosensor for point-of-care in situ wound monitoring.
Gao, Yuji; Nguyen, Dat T; Yeo, Trifanny; Lim, Su Bin; Tan, Wei Xian; Madden, Leigh Edward; Jin, Lin; Long, Ji Yong Kenan; Aloweni, Fazila Abu Bakar; Liew, Yi Jia Angela; Tan, Mandy Li Ling; Ang, Shin Yuh; Maniya, Sivagame D/O; Abdelwahab, Ibrahim; Loh, Kian Ping; Chen, Chia-Hung; Becker, David Laurence; Leavesley, David; Ho, John S; Lim, Chwee Teck.
Afiliación
  • Gao Y; Institute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore. yujigao2021@gmail.com ctlim@nus.edu.sg.
  • Nguyen DT; Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore 119077, Singapore.
  • Yeo T; Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.
  • Lim SB; Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
  • Tan WX; Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
  • Madden LE; Nursing, Singapore General Hospital, Singapore 168753, Singapore.
  • Jin L; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
  • Long JYK; Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
  • Aloweni FAB; Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.
  • Liew YJA; Nursing, Singapore General Hospital, Singapore 168753, Singapore.
  • Tan MLL; Nursing, Singapore General Hospital, Singapore 168753, Singapore.
  • Ang SY; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
  • Maniya SD; Nursing, Singapore General Hospital, Singapore 168753, Singapore.
  • Abdelwahab I; Nursing, Singapore General Hospital, Singapore 168753, Singapore.
  • Loh KP; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.
  • Chen CH; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.
  • Becker DL; Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.
  • Leavesley D; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
  • Ho JS; Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.
  • Lim CT; Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.
Sci Adv ; 7(21)2021 05.
Article en En | MEDLINE | ID: mdl-34020961
Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor-α, interleukin-6 (IL-6), IL-8, and transforming growth factor-ß1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Sistemas de Atención de Punto Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Sistemas de Atención de Punto Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos