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Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit.
Hiramoto, Atsuki; Jonaitis, Julius; Niki, Sawako; Kohsaka, Hiroshi; Fetter, Richard D; Cardona, Albert; Pulver, Stefan R; Nose, Akinao.
Afiliación
  • Hiramoto A; Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
  • Jonaitis J; School of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.
  • Niki S; Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
  • Kohsaka H; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
  • Fetter RD; Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
  • Cardona A; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Pulver SR; HHMI Janelia Research Campus, Ashburn, VA, USA.
  • Nose A; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Nat Commun ; 12(1): 2943, 2021 05 19.
Article en En | MEDLINE | ID: mdl-34011945
Typical patterned movements in animals are achieved through combinations of contraction and delayed relaxation of groups of muscles. However, how intersegmentally coordinated patterns of muscular relaxation are regulated by the neural circuits remains poorly understood. Here, we identify Canon, a class of higher-order premotor interneurons, that regulates muscular relaxation during backward locomotion of Drosophila larvae. Canon neurons are cholinergic interneurons present in each abdominal neuromere and show wave-like activity during fictive backward locomotion. Optogenetic activation of Canon neurons induces relaxation of body wall muscles, whereas inhibition of these neurons disrupts timely muscle relaxation. Canon neurons provide excitatory outputs to inhibitory premotor interneurons. Canon neurons also connect with each other to form an intersegmental circuit and regulate their own wave-like activities. Thus, our results demonstrate how coordinated muscle relaxation can be realized by an intersegmental circuit that regulates its own patterned activity and sequentially terminates motor activities along the anterior-posterior axis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Drosophila melanogaster / Interneuronas / Relajación Muscular Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Drosophila melanogaster / Interneuronas / Relajación Muscular Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido