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MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer.
Quintanilha, Julia C F; Cursino, Maria A; Borges, Jessica B; Torso, Nadine G; Bastos, Larissa B; Oliveira, Juliana M; Cobaxo, Thiago S; Pincinato, Eder C; Hirata, Mario H; Geraldo, Murilo V; Lima, Carmen S P; Moriel, Patricia.
Afiliación
  • Quintanilha JCF; School of Medical Science, University of Campinas, Campinas, São Paulo, Brazil.
  • Cursino MA; School of Medical Science, University of Campinas, Campinas, São Paulo, Brazil.
  • Borges JB; Dante Pazzanese Institute of Cardiology, São Paulo, Brazil.
  • Torso NG; Faculty of Pharmaceutical Sciences, University of Campinas, 200 Cândido Portinari Street, Campinas, São Paulo, 13083-871, Brazil.
  • Bastos LB; Faculty of Pharmaceutical Sciences, University of Campinas, 200 Cândido Portinari Street, Campinas, São Paulo, 13083-871, Brazil.
  • Oliveira JM; Faculty of Pharmaceutical Sciences, University of Campinas, 200 Cândido Portinari Street, Campinas, São Paulo, 13083-871, Brazil.
  • Cobaxo TS; Faculty of Pharmaceutical Sciences, University of Campinas, 200 Cândido Portinari Street, Campinas, São Paulo, 13083-871, Brazil.
  • Pincinato EC; School of Medical Science, University of Campinas, Campinas, São Paulo, Brazil.
  • Hirata MH; Dante Pazzanese Institute of Cardiology, São Paulo, Brazil.
  • Geraldo MV; Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Lima CSP; Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Moriel P; School of Medical Science, University of Campinas, Campinas, São Paulo, Brazil.
BMC Cancer ; 21(1): 575, 2021 May 19.
Article en En | MEDLINE | ID: mdl-34011306
BACKGROUND: No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin. METHODS: We performed microRNA (miRNA) sequencing using plasma collected 5 days after cisplatin treatment (D5) from twelve patients with head and neck cancer with and without nephrotoxicity (grade ≥ 2 increased serum creatinine). The most differentially expressed miRNAs between the two groups were selected for quantification at baseline and D5 in a larger cohort of patients. The association between miRNAs and nephrotoxicity was evaluated by calculating the odds ratio (OR) from univariate logistic regression. Receiver operating characteristic curves (ROC) were used to estimate the area under the curve (AUC), sensitivity, and specificity. RESULTS: MiR-3168 (p = 1.98 × 10- 8), miR-4718 (p = 4.24 × 10- 5), and miR-6125 (p = 6.60 × 10- 5) were the most differentially expressed miRNAs and were further quantified in 43, 48, and 53 patients, respectively. The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). MiR-4718 showed the highest AUC (0.77, 95% CI: 0.61-0.93) with sensitivity of 66.76 and specificity of 79.49. CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Cisplatino / MicroARNs / Lesión Renal Aguda / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Cisplatino / MicroARNs / Lesión Renal Aguda / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido