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Influence of Pediatric Endoscopic Endonasal Skull Base Resections on Midface and Skull Base Development.
Oviedo, Parisa; Zamora, Steven; Vinocur, Daniel; Levy, Michael L; Nation, Javan.
Afiliación
  • Oviedo P; University of California San Diego School of Medicine, La Jolla, California, USA.
  • Zamora S; Division of Pediatric Otolaryngology, Rady Children's Hospital San Diego, San Diego, California, USA.
  • Vinocur D; University of California San Diego School of Medicine, La Jolla, California, USA.
  • Levy ML; Division of Pediatric Radiology, Rady Children's Hospital San Diego, San Diego, California, USA.
  • Nation J; University of California San Diego School of Medicine, La Jolla, California, USA.
Pediatr Neurosurg ; 56(4): 345-356, 2021.
Article en En | MEDLINE | ID: mdl-34010830
OBJECTIVE: The purpose of this study is to use imaging data to determine if endoscopic endonasal surgery (EES) for skull base tumor resection interrupts skull base growth and development, resulting in an atrophic midface skeletal structure, compared to matched normal controls. METHODS: Data were collected by a retrospective chart review done on children aged 16 years and below who underwent endoscopic tumor resection and had pre- and postoperative magnetic resonance imaging with relevant midface anatomy. 121 normal controls were matched to 20 EES patients by age and gender. Three measurements related to midface anatomy were taken from 1 sagittal T1 slice and 1 axial T2 slice of each scan. Statistical analysis was used to compare growth measures between cases and controls. RESULTS: Twenty patients who underwent EES between November 2015 and April 2018 met our inclusion criteria. The mean age of the patients, 11 males and 9 females, was 10 years, and 8 patients (38%) were aged 7 years or younger. Six patients who had a high-flow CSF leak obtained a nasoseptal flap. A student T test and multivariate regression analysis found that EES did not affect midface and skull base growth. Among the variables assessed, age appears to be the only driver of growth. CONCLUSION: There were no identified differences in craniofacial growth in pediatric patients undergoing EES for skull base tumor resection as compared to the control group. EES does not appear to significantly interfere with midface/skull base development and is a good surgical option for pediatric patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Base del Cráneo / Procedimientos de Cirugía Plástica Tipo de estudio: Observational_studies / Prognostic_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Pediatr Neurosurg Asunto de la revista: NEUROCIRURGIA / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Base del Cráneo / Procedimientos de Cirugía Plástica Tipo de estudio: Observational_studies / Prognostic_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Pediatr Neurosurg Asunto de la revista: NEUROCIRURGIA / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza