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A Case of Bilateral Multifocal Choroiditis Associated with BRAF/MEK Inhibitor Use for Metastatic Cutaneous Melanoma.
Yanagihara, Ryan T; Tom, Elysse S; Seitzman, Gerami D; Saraf, Steven S.
Afiliación
  • Yanagihara RT; Department of Ophthalmology, University of Washington, Seattle, Washington, USA.
  • Tom ES; Department of Ophthalmology, University of Washington, Seattle, Washington, USA.
  • Seitzman GD; Department of Ophthalmology, Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
  • Saraf SS; Department of Ophthalmology, University of Washington, Seattle, Washington, USA.
Ocul Immunol Inflamm ; 30(7-8): 2005-2009, 2022.
Article en En | MEDLINE | ID: mdl-34009099
PURPOSE: To report a case of BRAF/MEK inhibitor-associated multifocal choroiditis that recurred after medication re-exposure and resolved after discontinuing BRAF/MEK inhibition and administering local steroid therapy. CASE REPORT: A 32-year-old woman with metastatic cutaneous melanoma on dabrafenib/trametinib presented with bilateral anterior uveitis and new bilateral multifocal chorioretinal scars. The anterior uveitis resolved after a course of topical steroids. She presented 18 months later with reactivation of bilateral multifocal choroiditis after starting encorafenib/binimetinib 1 month prior. The chorioretinal lesions appeared elevated with associated vitreous cell. Indocyanine angiography showed numerous foci of new choroiditis, more pronounced in the left eye. Encorafenib/binimetinib was discontinued and a subtenon triamcinolone injection was administered to the left eye. Her symptoms improved and the choroiditis resolved. CONCLUSION: BRAF/MEK inhibitors may be associated with ocular toxicity manifesting as multifocal choroiditis. The increasing use of these agents and risk of visual impairment warrants early detection and management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Uveítis Anterior / Melanoma Tipo de estudio: Risk_factors_studies / Screening_studies Límite: Adult / Humans Idioma: En Revista: Ocul Immunol Inflamm Asunto de la revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Uveítis Anterior / Melanoma Tipo de estudio: Risk_factors_studies / Screening_studies Límite: Adult / Humans Idioma: En Revista: Ocul Immunol Inflamm Asunto de la revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido