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Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence.
Iamjan, Sri-Arun; Thanoi, Samur; Watiktinkorn, Paritat; Fachim, Helene; Dalton, Caroline F; Nudmamud-Thanoi, Sutisa; Reynolds, Gavin P.
Afiliación
  • Iamjan SA; Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
  • Thanoi S; Centre of Excellence in Medical Biotechnology, Naresuan University, Phitsanulok 65000, Thailand.
  • Watiktinkorn P; Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand.
  • Fachim H; Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
  • Dalton CF; Centre of Excellence in Medical Biotechnology, Naresuan University, Phitsanulok 65000, Thailand.
  • Nudmamud-Thanoi S; Synphaet Hospital, Bangkok 10230, Thailand.
  • Reynolds GP; Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK.
Epigenomics ; 13(12): 953-965, 2021 06.
Article en En | MEDLINE | ID: mdl-34008409
Lay abstract The effects of methamphetamine (METH), an addictive psychostimulant drug, on changes of DNA methylation of an important regulator of neuronal survival, BDNF, were examined in blood of METH-dependent patients and in the brain of METH-administered rats. BDNF methylation was increased in patients and in the prefrontal cortex of METH-administered rats, while rat hippocampus showed a reduction of Bdnf methylation, with an equivalent increase in gene expression. The methylation increases in humans were greatest in those with a METH-induced psychosis. Although a relationship between Bdnf methylation and its expression has not been proven, changes of BDNF DNA methylation are associated with METH dependence, especially METH-dependent psychosis, suggesting that METH neurotoxicity may relate to the effects of changes in BDNF methylation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Exones / Factor Neurotrófico Derivado del Encéfalo / Metilación de ADN / Trastornos Relacionados con Anfetaminas / Predisposición Genética a la Enfermedad / Metanfetamina Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Epigenomics Año: 2021 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Exones / Factor Neurotrófico Derivado del Encéfalo / Metilación de ADN / Trastornos Relacionados con Anfetaminas / Predisposición Genética a la Enfermedad / Metanfetamina Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Epigenomics Año: 2021 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido