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Small-molecule inhibitor targeting the Hsp70-Bim protein-protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance.
Song, Ting; Guo, Yafei; Xue, Zuguang; Guo, Zongwei; Wang, Ziqian; Lin, Donghai; Zhang, Hong; Pan, Hao; Zhang, Xiaodong; Yin, Fangkui; Wang, Hang; Uwituze, Laura Bonnette; Zhang, Zhichao.
Afiliación
  • Song T; State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
  • Guo Y; School of Life Science and Technology, Dalian University of Technology, Dalian, Liaoning, China.
  • Xue Z; Department of Hematology, Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
  • Guo Z; School of Life Science and Technology, Dalian University of Technology, Dalian, Liaoning, China.
  • Wang Z; State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
  • Lin D; The Key Laboratory for Chemical Biology of Fujian Province, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China. dhlin@xmu.edu.cn.
  • Zhang H; School of Life Science and Technology, Dalian University of Technology, Dalian, Liaoning, China.
  • Pan H; State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
  • Zhang X; State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
  • Yin F; State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
  • Wang H; School of Innovation and Entrepreneurship, Dalian University of Technology, Dalian, Liaoning, China.
  • Uwituze LB; State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
  • Zhang Z; State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China. zczhang@dlut.edu.cn.
Leukemia ; 35(10): 2862-2874, 2021 10.
Article en En | MEDLINE | ID: mdl-34007045
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Regulación Leucémica de la Expresión Génica / Proteínas de Fusión bcr-abl / Proteínas HSP70 de Choque Térmico / Resistencia a Antineoplásicos / Bibliotecas de Moléculas Pequeñas / Dominios y Motivos de Interacción de Proteínas / Proteína 11 Similar a Bcl2 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Regulación Leucémica de la Expresión Génica / Proteínas de Fusión bcr-abl / Proteínas HSP70 de Choque Térmico / Resistencia a Antineoplásicos / Bibliotecas de Moléculas Pequeñas / Dominios y Motivos de Interacción de Proteínas / Proteína 11 Similar a Bcl2 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido