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Ultra-High Field Magnetic Resonance Imaging of the Retrobulbar Optic Nerve, Subarachnoid Space, and Optic Nerve Sheath in Emmetropic and Myopic Eyes.
Nguyen, Bao N; Cleary, Jon O; Glarin, Rebecca; Kolbe, Scott C; Moffat, Bradford A; Ordidge, Roger J; Bui, Bang V; McKendrick, Allison M.
Afiliación
  • Nguyen BN; Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia.
  • Cleary JO; Melbourne Brain Centre Imaging Unit, Department of Medicine and Radiology, The University of Melbourne, Parkville, Victoria, Australia.
  • Glarin R; Department of Radiology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
  • Kolbe SC; Melbourne Brain Centre Imaging Unit, Department of Medicine and Radiology, The University of Melbourne, Parkville, Victoria, Australia.
  • Moffat BA; Department of Radiology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
  • Ordidge RJ; Melbourne Brain Centre Imaging Unit, Department of Medicine and Radiology, The University of Melbourne, Parkville, Victoria, Australia.
  • Bui BV; Department of Neuroscience, Central Clinical School, Monash University, Australia.
  • McKendrick AM; Melbourne Brain Centre Imaging Unit, Department of Medicine and Radiology, The University of Melbourne, Parkville, Victoria, Australia.
Transl Vis Sci Technol ; 10(2): 8, 2021 02 05.
Article en En | MEDLINE | ID: mdl-34003892
Purpose: We aimed to image the optic nerve, subarachnoid space and optic nerve sheath in emmetropes and myopes ultra-high field (7-Tesla) magnetic resonance imaging (MRI). We targeted the retrobulbar distance of approximately 3 mm behind the eyeball, an area of clinical interest because of optic nerve sheath distensibility and pressure-related enlargement. Methods: Eleven emmetropes (+0.75 to -0.50D, aged 20-41 years) and 10 myopes (-4.5 to -12D, aged 21-37 years) participated. Cross-sectional area of the optic nerve, subarachnoid space and optic nerve sheath at approximately 3 mm behind the eye were measured from two-dimensional T2-weighted coronal oblique MRI images obtained through the left optic nerve. Axial length of the left eye was measured from T2-weighted axial MRI images. In nine emmetropes and seven myopes, the optic nerve head was imaged with optical coherence tomography to compare retrobulbar and intraocular measures. Results: Retrobulbar optic nerve, subarachnoid space and optic nerve sheath dimensions differed between myopes and emmetropes. Myopes tended to have smaller optic nerve and subarachnoid space. Longer MRI-derived axial length was associated with smaller optic nerve area (P = 0.03). Bruch's membrane opening area did not predict retrobulbar optic nerve area (P = 0.48). Conclusions: This study demonstrates the feasibility of using 7-Tesla MRI to measure optic nerve, subarachnoid space, and optic nerve sheath dimensions behind the eye. In healthy adults, the retrobulbar optic nerve and subarachnoid space size are influenced by the degree of myopia. Translational Relevance: ultra-high field MRI is a practical tool for assessing the morphometry of the optic nerve and surrounding anatomy behind the eye.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Emetropía / Miopía Límite: Adult / Humans Idioma: En Revista: Transl Vis Sci Technol Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Emetropía / Miopía Límite: Adult / Humans Idioma: En Revista: Transl Vis Sci Technol Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos