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Circulating immunity protects the female reproductive tract from Chlamydia infection.
Labuda, Jasmine C; Pham, Oanh H; Depew, Claire E; Fong, Kevin D; Lee, Bokyung S; Rixon, Jordan A; McSorley, Stephen J.
Afiliación
  • Labuda JC; Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Pham OH; Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Depew CE; Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Fong KD; Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Lee BS; Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Rixon JA; Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • McSorley SJ; Center for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616 sjmcsorley@ucdavis.edu.
Proc Natl Acad Sci U S A ; 118(21)2021 05 25.
Article en En | MEDLINE | ID: mdl-34001624
Anatomical positioning of memory lymphocytes within barrier tissues accelerates secondary immune responses and is thought to be essential for protection at mucosal surfaces. However, it remains unclear whether resident memory in the female reproductive tract (FRT) is required for Chlamydial immunity. Here, we describe efficient generation of tissue-resident memory CD4 T cells and memory lymphocyte clusters within the FRT after vaginal infection with Chlamydia Despite robust establishment of localized memory lymphocytes within the FRT, naïve mice surgically joined to immune mice, or mice with only circulating immunity following intranasal immunization, were fully capable of resisting Chlamydia infection via the vaginal route. Blocking the rapid mobilization of circulating memory CD4 T cells to the FRT inhibited this protective response. These data demonstrate that secondary protection in the FRT can occur in the complete absence of tissue-resident immune cells. The ability to confer robust protection to barrier tissues via circulating immune memory provides an unexpected opportunity for vaccine development against infections of the FRT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Infecciones por Chlamydia / Inmunización / Chlamydia muridarum / Genitales Femeninos / Anticuerpos Antibacterianos Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Infecciones por Chlamydia / Inmunización / Chlamydia muridarum / Genitales Femeninos / Anticuerpos Antibacterianos Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos