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Coupling between slow waves and sharp-wave ripples engages distributed neural activity during sleep in humans.
Skelin, Ivan; Zhang, Haoxin; Zheng, Jie; Ma, Shiting; Mander, Bryce A; Kim McManus, Olivia; Vadera, Sumeet; Knight, Robert T; McNaughton, Bruce L; Lin, Jack J.
Afiliación
  • Skelin I; Department of Neurology, University of California, Irvine, CA 92603; iskelin@uci.edu linjj@hs.uci.edu.
  • Zhang H; Department of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
  • Zheng J; Department of Neurology, University of California, Irvine, CA 92603.
  • Ma S; Department of Biomedical Engineering, University of California, Irvine, CA 92603.
  • Mander BA; Department of Biomedical Engineering, University of California, Irvine, CA 92603.
  • Kim McManus O; Department of Neurology, University of California, Irvine, CA 92603.
  • Vadera S; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92603.
  • Knight RT; Department of Neurosciences, University of California, San Diego, CA 92093.
  • McNaughton BL; Division of Neurology, Rady Children's Hospital, San Diego, CA 92123.
  • Lin JJ; Department of Neurological Surgery, University of California, Irvine, CA 92603.
Proc Natl Acad Sci U S A ; 118(21)2021 05 25.
Article en En | MEDLINE | ID: mdl-34001599
Hippocampal-dependent memory consolidation during sleep is hypothesized to depend on the synchronization of distributed neuronal ensembles, organized by the hippocampal sharp-wave ripples (SWRs, 80 to 150 Hz), subcortical/cortical slow-wave activity (SWA, 0.5 to 4 Hz), and sleep spindles (SP, 7 to 15 Hz). However, the precise role of these interactions in synchronizing subcortical/cortical neuronal activity is unclear. Here, we leverage intracranial electrophysiological recordings from the human hippocampus, amygdala, and temporal and frontal cortices to examine activity modulation and cross-regional coordination during SWRs. Hippocampal SWRs are associated with widespread modulation of high-frequency activity (HFA, 70 to 200 Hz), a measure of local neuronal activation. This peri-SWR HFA modulation is predicted by the coupling between hippocampal SWRs and local subcortical/cortical SWA or SP. Finally, local cortical SWA phase offsets and SWR amplitudes predicted functional connectivity between the frontal and temporal cortex during individual SWRs. These findings suggest a selection mechanism wherein hippocampal SWR and cortical slow-wave synchronization governs the transient engagement of distributed neuronal populations supporting hippocampal-dependent memory consolidation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Electrocorticografía / Consolidación de la Memoria / Hipocampo Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Electrocorticografía / Consolidación de la Memoria / Hipocampo Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos