Your browser doesn't support javascript.
loading
3D Printed Zn-doped Mesoporous Silica-incorporated Poly-L-lactic Acid Scaffolds for Bone Repair.
Qian, Guowen; Zhang, Lemin; Wang, Guoyong; Zhao, Zhengyu; Peng, Shuping; Shuai, Cijun.
Afiliación
  • Qian G; Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China.
  • Zhang L; Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China.
  • Wang G; Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China.
  • Zhao Z; Shenzhen Institute of Information Technology, Shenzhen 518172, China.
  • Peng S; NHC Key Laboratory of Carcinogenesis, School of basic Medical Science, Central South University, Changsha, Hunan 410013, China.
  • Shuai C; School of Energy and Machinery Engineering, Jiangxi University of Science and Technology, Nanchang 330013, China.
Int J Bioprint ; 7(2): 346, 2021.
Article en En | MEDLINE | ID: mdl-33997435
Poly-L-lactic acid (PLLA) lacks osteogenic activity, which limits its application in bone repair. Zinc (Zn) is widely applied to strengthen the biological properties of polymers due to its excellent osteogenic activity. In the present study, Zn-doped mesoporous silica (Zn-MS) particles were synthesized by one-pot hydrothermal method. Then, the particles were induced into PLLA scaffolds prepared by selective laser sintering technique, aiming to improve their osteogenic activity. Our results showed that the synthesized particles possessed rosette-like morphology and uniform mesoporous structure, and the composite scaffold displayed the sustained release of Zn ion in a low concentration range, which was attributed to the shield effect of the PLLA matrix and the strong bonding interaction of Si-O-Zn. The scaffold could evidently promote osteogenesis differentiation of mouse bone marrow mesenchymal stem cells by upregulating their osteogenesis-related gene expression. Besides, Zn-MS particles could significantly increase the compressive strength of the PLLA scaffold because of their rosette-like morphology and mesoporous structure, which can form micromechanical interlocking with the PLLA matrix. The Zn-MS particles possess great potential to improve various polymer scaffold properties due to their advantageous morphology and physicochemical properties.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Bioprint Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Bioprint Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur