IBSP, a potential recurrence biomarker, promotes the progression of colorectal cancer via Fyn/ß-catenin signaling pathway.

Chen, Yan; Qin, Ying; Dai, Mengmeng; Liu, Liping; Ni, Yong; Sun, Qinsheng; Li, Lulu; Zhou, Yaoyao; Qiu, Cheng; Jiang, Yuyang

Chen, Yan; Qin, Ying; Dai, Mengmeng; Liu, Liping; Ni, Yong; Sun, Qinsheng; Li, Lulu; Zhou, Yaoyao; Qiu, Cheng; Jiang, Yuyang.

Afiliación

Chen Y; School of Life Sciences, Tsinghua University, Beijing, China.
Qin Y; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China.
Dai M; National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China.
Liu L; Department of Gastrointestinal Surgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Ni Y; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China.
Sun Q; Department of Hepatobiliary and Pancrease Surgery, Shenzhen People's Hospital, Shenzhen, Guangdong, China.
Li L; Department of Hepatopancreatobiliary Surgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Zhou Y; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China.
Qiu C; National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China.
Jiang Y; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China.

Cancer Med ; 10(12): 4030-4045, 2021 06.

Article en En | MEDLINE | ID: mdl-33987980

Asunto(s)

Biomarcadores de Tumor/genética; Neoplasias Colorrectales/genética; Progresión de la Enfermedad; Sialoproteína de Unión a Integrina/genética; Recurrencia Local de Neoplasia/genética; Apoptosis; Biomarcadores de Tumor/sangre; Biomarcadores de Tumor/metabolismo; Proliferación Celular; Colon/metabolismo; Neoplasias Colorrectales/metabolismo; Neoplasias Colorrectales/mortalidad; Neoplasias Colorrectales/patología; Bases de Datos Genéticas; Regulación hacia Abajo; Femenino; Humanos; Sialoproteína de Unión a Integrina/sangre; Sialoproteína de Unión a Integrina/metabolismo; Masculino; Persona de Mediana Edad; Recurrencia Local de Neoplasia/metabolismo; Recurrencia Local de Neoplasia/mortalidad; Proteínas Proto-Oncogénicas c-fyn/metabolismo; ARN/metabolismo; ARN Mensajero/metabolismo; beta Catenina/metabolismo

Palabras clave

Fyn/ß-catenin signaling pathway; colorectal cancer; diagnosis and treatment; integrin-binding sialoprotein (IBSP); metastatic recurrence

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Progresión de la Enfermedad / Sialoproteína de Unión a Integrina / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Med Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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