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Venetoclax and Daratumumab combination treatment demonstrates pre-clinical efficacy in mouse models of Acute Myeloid Leukemia.
Mistry, Jayna J; Hellmich, Charlotte; Lambert, Amelia; Moore, Jamie A; Jibril, Aisha; Collins, Angela; Bowles, Kristian M; Rushworth, Stuart A.
Afiliación
  • Mistry JJ; Norwich Medical School, University of East Anglia, Norwich Research Park, NR4 7UQ, Norwich, UK.
  • Hellmich C; Earlham Institute, Norwich Research Park, NR4 7UH, Norwich, UK.
  • Lambert A; Norwich Medical School, University of East Anglia, Norwich Research Park, NR4 7UQ, Norwich, UK.
  • Moore JA; Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, NR4 7UY, Norwich, UK.
  • Jibril A; Norwich Medical School, University of East Anglia, Norwich Research Park, NR4 7UQ, Norwich, UK.
  • Collins A; Norwich Medical School, University of East Anglia, Norwich Research Park, NR4 7UQ, Norwich, UK.
  • Bowles KM; Norwich Medical School, University of East Anglia, Norwich Research Park, NR4 7UQ, Norwich, UK.
  • Rushworth SA; Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, NR4 7UY, Norwich, UK.
Biomark Res ; 9(1): 35, 2021 May 13.
Article en En | MEDLINE | ID: mdl-33985565
Acute myeloid leukemia (AML) remains an incurable malignancy despite recent advances in treatment. Recently a number of new therapies have emerged for the treatment of AML which target BCL-2 or the membrane receptor CD38. Here, we show that treatment with Venetoclax and Daratumumab combination resulted in a slower tumor progression and a reduced leukemia growth both in vitro and in vivo. These data provide evidence for clinical evaluation of Venetoclax and Daratumumab combination in the treatment of AML.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomark Res Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomark Res Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido