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Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia.
Ge, Haixia; Zhang, Weitao; Yuan, Kai; Xue, Hanyue; Cheng, Hao; Chen, Weijiao; Xie, Yishi; Zhang, Jian; Xu, Xiaojun; Yang, Peng.
Afiliación
  • Ge H; School of Life Sciences, Huzhou University, Huzhou, 313000, China.
  • Zhang W; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Yuan K; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Xue H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Cheng H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Chen W; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Xie Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Zhang J; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Xu X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: xiaojunxu2000@163.com.
  • Yang P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: pengyang@cpu.edu.cn.
Eur J Med Chem ; 221: 113522, 2021 Oct 05.
Article en En | MEDLINE | ID: mdl-33984804
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcaloides de Berberina / Diseño de Fármacos / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Proteína 2 de Unión a Elementos Reguladores de Esteroles / Hiperlipidemias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcaloides de Berberina / Diseño de Fármacos / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Proteína 2 de Unión a Elementos Reguladores de Esteroles / Hiperlipidemias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia