Electrostatic modulation of hnRNPA1 low-complexity domain liquid-liquid phase separation and aggregation.

Tsoi, Phoebe S; Quan, My Diem; Choi, Kyoung-Jae; Dao, Khoa M; Ferreon, Josephine C; Ferreon, Allan Chris M

Tsoi, Phoebe S; Quan, My Diem; Choi, Kyoung-Jae; Dao, Khoa M; Ferreon, Josephine C; Ferreon, Allan Chris M.

Afiliación

Tsoi PS; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Quan MD; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Choi KJ; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Dao KM; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Ferreon JC; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Ferreon ACM; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.

Protein Sci ; 30(7): 1408-1417, 2021 07.

Article en En | MEDLINE | ID: mdl-33982369

Asunto(s)

Ribonucleoproteína Nuclear Heterogénea A1/química; Proteínas Intrínsecamente Desordenadas/química; Agregado de Proteínas; Humanos; Dominios Proteicos; Electricidad Estática

Palabras clave

ALS; LLPS; hnRNPA1; intrinsically disordered protein; neurodegenerative diseases; protein aggregation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Intrínsecamente Desordenadas / Agregado de Proteínas / Ribonucleoproteína Nuclear Heterogénea A1 Límite: Humans Idioma: En Revista: Protein Sci Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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