Your browser doesn't support javascript.
loading
Precise Identification of the Dimethyl Sulfoxide Triggered Tricarbonyldichlororuthenium(II) Dimer for Releasing CO.
Zhu, Jiangrui; Wang, Juanjuan; Wang, Guosheng; Zhang, Jia; Tao, Wei; Liu, Chang; Liu, Ming; Zhang, Hao; Xie, Ruipei; Ye, Fangfu; Liu, Ying; Fang, Weihai; Chen, Xuebo; Li, Yunliang.
Afiliación
  • Zhu J; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
  • Wang J; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Wang G; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Zhang J; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Tao W; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
  • Liu C; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Liu M; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Zhang H; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Xie R; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
  • Ye F; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
  • Liu Y; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
  • Fang W; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Chen X; Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China.
  • Li Y; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
J Phys Chem Lett ; 12(19): 4658-4665, 2021 May 20.
Article en En | MEDLINE | ID: mdl-33978423
Low concentrations of carbon monoxide (CO) can play vital roles in pharmacological and physiological functions in the human body. The transition-metal carbonyl complexes of the tricarbonyldichlororuthenium(II) dimer [Ru2(CO)6Cl4 (CORM-2)] were proposed as CO-releasing molecules (CORMs) to improve the delivery efficiency of CO for therapeutic effects. The accurate identification of final products for CORMs in solution and the detailed mechanisms of the release of CO were the essential prerequisite for its effective physiological application, which have been deficient. In this study, utilizing the cutting-edge two-dimensional (2D) IR spectroscopy, with the intrinsic vibrational modes and the coupling information on dynamics of intramolecular vibrational energy redistribution (IVR), the final products of A, B, C, and E are accurately identified when CORM-2 is dissolved in dimethyl sulfoxide (DMSO). Furthermore, with the clues on intermolecular interaction and chemical exchange dynamics between different products, the transformations between different products are also directly characterized for the first time. These findings challenge the results from the classic 1D spectroscopic pattern, and they evidently demonstrated that the release of CO from CORM-2 in DMSO was slow and complicated with multiple reaction pathways. Combining with DFT simulations, the detailed mechanisms of release of CO for CORM-2 dissolved in DMSO are schematically proposed, which can significantly contribute to its drug optimization and pharmacological as well as physiological applications.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: J Phys Chem Lett Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Revista: J Phys Chem Lett Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos