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Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma: An International Multi-Institutional Analysis.
Schulte, Jefree J; Chapel, David B; Attanoos, Richard; Brcic, Luka; Burn, Juliet; Butnor, Kelly J; Chang, Nina; Chen, Heather; Dacic, Sanja; De Perrot, Marc; Fukuoka, Junya; Galateau-Salle, Francoise; Godschachner, Theresa; Hiroshima, Kenzo; Klebe, Sonja; Krausz, Thomas; Litzky, Leslie; Marchevsky, Alberto M; Mueller, Jeffrey; Nabeshima, Kazuki; Nicholson, Andrew G; Pal, Prodipto; Roden, Anja C; Rorvig, Sara; Santoni-Rugiu, Eric; Tazelaar, Henry; Tsao, Ming-Sound; Walts, Ann E; Weynand, Birgit; Zaizen, Yoshiaki; Zhang, Yu Zhi; Husain, Aliya N.
Afiliación
  • Schulte JJ; Department of Pathology, University of Chicago, Chicago, IL, USA.
  • Chapel DB; Department of Pathology and Lab Medicine, University of Wisconsin, Madison, WI, USA.
  • Attanoos R; Department of Pathology, University of Chicago, Chicago, IL, USA.
  • Brcic L; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
  • Burn J; Department of Cellular Pathology, University Hospital of Wales and School of Medicine, Cardiff University, Cardiff, UK.
  • Butnor KJ; Diagnostics and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
  • Chang N; Douglass Hanly Moir Pathology, Sydney, Australia.
  • Chen H; Department of Pathology, University of Vermont Medical Center, Burlington, VT, USA.
  • Dacic S; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada.
  • De Perrot M; Department of Pathology, University of Chicago, Chicago, IL, USA.
  • Fukuoka J; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Galateau-Salle F; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada.
  • Godschachner T; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Hiroshima K; Department of Pathology, MESOPATH-MESOBANK, Centre León Bérard, Lyon, France.
  • Klebe S; Diagnostics and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
  • Krausz T; Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
  • Litzky L; Department of Anatomical Pathology, SA Pathology, Flinders University, Adelaide, Australia.
  • Marchevsky AM; Department of Pathology, University of Chicago, Chicago, IL, USA.
  • Mueller J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Nabeshima K; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Nicholson AG; Department of Pathology, University of Chicago, Chicago, IL, USA.
  • Pal P; Department of Pathology, Fukuoka University Hospital, Fukuoka, Japan.
  • Roden AC; Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.
  • Rorvig S; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada.
  • Santoni-Rugiu E; Department of Laboratory Medicine and Pathology; Mayo Clinic, Rochester, MN, USA.
  • Tazelaar H; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Tsao MS; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Walts AE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, USA.
  • Weynand B; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada.
  • Zaizen Y; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Zhang YZ; Department of Pathology, Universitair Ziekenhuis Leuven, Leuven, Belgium.
  • Husain AN; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Am J Clin Pathol ; 156(6): 989-999, 2021 Nov 08.
Article en En | MEDLINE | ID: mdl-33978147
OBJECTIVES: Numerous studies on malignant mesothelioma (MM) highlight the prognostic importance of histologic subtype, nuclear grade, and necrosis. This study compares these parameters in paired biopsy and resection specimens of pleural MM. METHODS: Histologic subtype, percentage of epithelioid morphology, nuclear grade, and the presence or absence of necrosis were compared in 429 paired biopsies and resection specimens of pleural MM from 19 institutions. RESULTS: Histologic subtype was concordant in 81% of cases (κ = 0.58). When compared with resection specimens, epithelioid morphology at biopsy had a positive predictive value (PPV) of 78.9% and a negative predictive value (NPV) of 93.5%; sarcomatoid morphology showed high PPV (92.9%) and NPV (99.3%), and biphasic morphology PPV was 89.7% and NPV was 79.7%. Agreement of the percentage of epithelioid morphology was fair (κ = 0.27). Nuclear grade and necrosis were concordant in 75% (κ = 0.59) and 81% (κ = 0.53) of cases, respectively. Nuclear grade showed moderate (κ = 0.53) and substantial (κ = 0.67) agreement from patients with and without neoadjuvant therapy, respectively, and necrosis showed moderate (κ = 0.47 and κ = 0.60) agreement, respectively, in the same subsets of paired specimens. CONCLUSIONS: Paired biopsy-resection specimens from pleural MM show overall moderate agreement in pathologic parameters. These findings may help guide postbiopsy management and triage of patients with MM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pleurales / Mesotelioma Maligno Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Clin Pathol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pleurales / Mesotelioma Maligno Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Clin Pathol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido