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Ginseng ameliorates exercise-induced fatigue potentially by regulating the gut microbiota.
Zhou, Shan-Shan; Zhou, Jing; Xu, Jin-Di; Shen, Hong; Kong, Ming; Yip, Ka-Man; Han, Quan-Bin; Zhao, Zhong-Zhen; Xu, Jun; Chen, Hu-Biao; Li, Song-Lin.
Afiliación
  • Zhou SS; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. davidxujun@hkbu.edu.hk hbchen@hkbu.edu.hk and Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, Jiangsu, People's Republic
  • Zhou J; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, Jiangsu, People's Republic of China. songlinli64@126.com.
  • Xu JD; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, Jiangsu, People's Republic of China. songlinli64@126.com and Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chines
  • Shen H; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, Jiangsu, People's Republic of China. songlinli64@126.com and Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chines
  • Kong M; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, Jiangsu, People's Republic of China. songlinli64@126.com and Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chines
  • Yip KM; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. davidxujun@hkbu.edu.hk hbchen@hkbu.edu.hk.
  • Han QB; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. davidxujun@hkbu.edu.hk hbchen@hkbu.edu.hk.
  • Zhao ZZ; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. davidxujun@hkbu.edu.hk hbchen@hkbu.edu.hk.
  • Xu J; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. davidxujun@hkbu.edu.hk hbchen@hkbu.edu.hk and Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, Jiangsu, People's Republic
  • Chen HB; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. davidxujun@hkbu.edu.hk hbchen@hkbu.edu.hk.
  • Li SL; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine and Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, Jiangsu, People's Republic of China. songlinli64@126.com and Department of Pharmaceutical Analysis, Hospital of Integrated Traditional Chines
Food Funct ; 12(9): 3954-3964, 2021 May 11.
Article en En | MEDLINE | ID: mdl-33977937
The therapeutic effects of water extract of ginseng (WEG) on exercise-induced fatigue (EF) have been reported in several previous studies, but the molecular mechanisms involved remain unexplored. In this study, the anti-EF effects of WEG were studied, and the potential mechanisms were discussed. We characterized the chemical components of WEG by ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) and high performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD), and then examined the anti-EF effects of WEG on a rat model of weight-loaded swimming with a focus on endogenous metabolism and gut microbiota. WEG contains abundant (90.15%, w/w) saccharides and ginsenosides with structurally diverse glycosyls. WEG taken orally showed strong anti-EF effects by ameliorating energy metabolism abnormality, oxidative stress, lipid peroxidation, inflammatory response, disorders in the metabolism of bile acid, amino acid, fatty acid and lipid, as well as the gut microbiota dysbiosis. Given that gut microbiota is significantly associated with energy expenditure, systemic inflammation and host metabolism, these findings suggest a potential central role of the gut microbiota in mediating the anti-EF effect of WEG. That is, the saccharides and ginsenosides in WEG serve as energy substrates for specific intestinal bacteria, thereby beneficially regulating the gut microbiota, and the reshaped gut microbial ecosystem then triggers several molecular and cellular signaling pathways (e.g. butyrate or TGR5 signals) to achieve the therapeutic effects on EF. The outcomes highlighted here enable deeper insight into how WEG overcomes EF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Esfuerzo Físico / Fatiga / Microbioma Gastrointestinal / Panax Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Food Funct Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Esfuerzo Físico / Fatiga / Microbioma Gastrointestinal / Panax Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Food Funct Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido