A simple criterion to design optimal non-pharmaceutical interventions for mitigating epidemic outbreaks.
J R Soc Interface
; 18(178): 20200803, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33975462
For mitigating the COVID-19 pandemic, much emphasis is made on implementing non-pharmaceutical interventions to keep the reproduction number below one. However, using that objective ignores that some of these interventions, like bans of public events or lockdowns, must be transitory and as short as possible because of their significant economic and societal costs. Here, we derive a simple and mathematically rigorous criterion for designing optimal transitory non-pharmaceutical interventions for mitigating epidemic outbreaks. We find that reducing the reproduction number below one is sufficient but not necessary. Instead, our criterion prescribes the required reduction in the reproduction number according to the desired maximum of disease prevalence and the maximum decrease of disease transmission that the interventions can achieve. We study the implications of our theoretical results for designing non-pharmaceutical interventions in 16 cities and regions during the COVID-19 pandemic. In particular, we estimate the minimal reduction of each region's contact rate necessary to control the epidemic optimally. Our results contribute to establishing a rigorous methodology to design optimal non-pharmaceutical intervention policies for mitigating epidemic outbreaks.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pandemias
/
COVID-19
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J R Soc Interface
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Reino Unido