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SARS-CoV-2 RNAaemia in children: An Iranian referral hospital-based study.
Pourakbari, Babak; Mahmoudi, Shima; Mahmoudieh, Yasmine; Eshaghi, Hamid; Navaeian, Amene; Rostamyan, Maryam; Mamishi, Setareh.
Afiliación
  • Pourakbari B; Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahmoudi S; Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahmoudieh Y; Department of Molecular and Cell Biology, University of California, Berkeley, USA.
  • Eshaghi H; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Navaeian A; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Rostamyan M; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Mamishi S; Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
J Med Virol ; 93(9): 5452-5457, 2021 09.
Article en En | MEDLINE | ID: mdl-33969515
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is generally detected in nasopharyngeal swabs, viral RNA can be found in other samples including blood. Recently, associations between SARS-CoV-2 RNAaemia and disease severity and mortality have been reported in adults, while no reports are available in pediatric patients with coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the mortality, severity, clinical, and laboratory findings of SARS-CoV-2 RNA detection in blood in 96 pediatric patients with confirmed COVID-19. Among all patients, 6 (6%) had SARS-CoV-2 RNAaemia. Out of the six patients with SARS-CoV-2 RNAaemia, four (67%) had a severe form of the disease, and two out of the 6 patients with SARS-CoV-2 RNAaemia passed away (33%). Our results show that the symptoms more commonly found in the cases of COVID-19 in the study (fever, cough, tachypnea, and vomiting), were found at a higher percentage in the patients with SARS-CoV-2 RNAaemia. Creatine phosphokinase and magnesium tests showed significant differences between the positive and negative SARS-CoV-2 RNAaemia groups. Among all laboratory tests, magnesium and creatine phosphokinase could better predict SARS-CoV-2 RNAemia with area under the curve  levels of 0.808 and 0.748, respectively. In conclusion, 67% of individuals with SARS-CoV-2 RNAaemia showed a severe COVID-19 and one-third of the patients with SARS-CoV-2 RNAaemia passed away. Our findings suggest that magnesium and creatine phosphokinase might be considered as markers to estimate the SARS-CoV-2 RNAaemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Viremia / ARN Viral / Creatina Quinasa / SARS-CoV-2 / COVID-19 / Magnesio Tipo de estudio: Diagnostic_studies / Prognostic_studies País/Región como asunto: Asia Idioma: En Revista: J Med Virol Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Viremia / ARN Viral / Creatina Quinasa / SARS-CoV-2 / COVID-19 / Magnesio Tipo de estudio: Diagnostic_studies / Prognostic_studies País/Región como asunto: Asia Idioma: En Revista: J Med Virol Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos