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Heterogeneity in outcome selection, definition and measurement in studies assessing the treatment of cryptoglandular anal fistula: findings from a systematic review.
Machielsen, A J H M; Iqbal, N; Kimman, M L; Sahnan, K; Adegbola, S O; Kane, G; Woodcock, R; Kleijnen, J; Grossi, U; Breukink, S O; Tozer, P J.
Afiliación
  • Machielsen AJHM; Department of Surgery and Colorectal Surgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.
  • Iqbal N; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
  • Kimman ML; Robin Phillips' Fistula Research Unit, St Mark's Hospital, London, UK. niqbal@doctors.org.uk.
  • Sahnan K; Department of Surgery and Cancer, Imperial College London, London, UK. niqbal@doctors.org.uk.
  • Adegbola SO; Department of Clinical Epidemiology and Medical Technology Assessment, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Centre+, Maastricht, The Netherlands.
  • Kane G; Robin Phillips' Fistula Research Unit, St Mark's Hospital, London, UK.
  • Woodcock R; Department of Surgery and Cancer, Imperial College London, London, UK.
  • Kleijnen J; Robin Phillips' Fistula Research Unit, St Mark's Hospital, London, UK.
  • Grossi U; Department of Surgery and Cancer, Imperial College London, London, UK.
  • Breukink SO; , Belfast, UK.
  • Tozer PJ; , London, UK.
Tech Coloproctol ; 25(7): 761-830, 2021 07.
Article en En | MEDLINE | ID: mdl-33963945
BACKGROUND: Treatment for cryptoglandular anal fistula (AF) is challenging and a lack of uniform outcomes in the literature prevents direct comparison of treatments. This can be addressed by developing a core outcome set, a standardised set of outcomes reported in all interventional studies for a specific condition. The aim of this systematic review is to assess the range of outcomes, their definitions, and the measurement instruments currently utilised in interventional studies for adult patients with AF. This will inform the development of an AF core outcome set. METHODS: Medline, Embase and The Cochrane Library were searched to identify all patient- and clinician-reported outcomes in studies assessing medical, surgical or combination treatment of adult patients with AF published from January 2008 to May 2020. The resulting outcomes were categorized according to the Core Outcome Measurement in Effectiveness Trials (COMET) taxonomy to better understand their distribution. RESULTS: In total, 155 studies were included, 552 outcomes were extracted, with a median of three outcomes (interquartile range 2-5) per study. Only 25% of studies demonstrated high-quality outcome reporting. The outcomes were merged into 52 unique outcomes and structured into four core areas and 14 domains, with the majority in the domain of physiological or clinical (gastrointestinal) outcomes. The most commonly reported outcomes were healing (77%), incontinence (63%), and recurrence (40%), with no single outcome assessed across all studies. There was a wide variation in outcome definitions and measurement instruments used. CONCLUSIONS: There is substantial heterogeneity in outcomes, definitions, and measurement instruments reported in interventional studies for cryptoglandular anal fistula. This emphasises the need for standardised outcome reporting and measurement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fístula Rectal Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: Tech Coloproctol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fístula Rectal Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: Tech Coloproctol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Italia