Insulin-like growth factors: Ligands, binding proteins, and receptors.

LeRoith, Derek; Holly, Jeff M P; Forbes, Briony E

LeRoith, Derek; Holly, Jeff M P; Forbes, Briony E.

Afiliación

LeRoith D; Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Holly JMP; Translational Health Sciences, Bristol Medical School, Learning & Research Building, Southmead Hospital, Bristol, BS10 5NB, UK. Electronic address: jeff.holly@bristol.ac.uk.
Forbes BE; Discipline of Medical Biochemistry, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, 5042, Australia.

Mol Metab ; 52: 101245, 2021 10.

Article en En | MEDLINE | ID: mdl-33962049

RESUMEN

BACKGROUND: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states. SCOPE OF REVIEW: Insulin and insulin receptors are the focus of other chapters in this series and will therefore not be discussed further. Here we review the basic components of the IGF system, their role in normal physiology and in critical pathology's. While this review concentrates on the role of IGFs in human physiology, animal models have been essential in providing understanding of the IGF system, and its regulation, and are briefly described. MAJOR CONCLUSIONS: IGF-I has effects via the circulation and locally within tissues to regulate cellular growth, differentiation, and survival, thereby controlling overall body growth. IGF-II levels are highest prenatally when it has important effects on growth. In adults, IGF-II plays important tissue-specific roles, including the maintenance of stem cell populations. Although the IGF-IR is closely related to the IR it has distinct physiological roles both on the cell surface and in the nucleus. The M6P/IGF-IIR, in contrast, is distinct and acts as a scavenger by mediating internalization and degradation of IGF-II. The IGFBPs bind IGF-I and IGF-II in the circulation to prolong their half-lives and modulate tissue access, thereby controlling IGF function. IGFBPs also have IGF ligand-independent cell effects.

Asunto(s)

Proteínas de Unión a Factor de Crecimiento Similar a la Insulina/metabolismo; Receptor de Insulina/metabolismo; Somatomedinas/metabolismo; Animales; Comunicación Celular; Humanos; Ligandos

Palabras clave

Cancer; Growth; Insulin-like growth factor binding proteins; Insulin-like growth factor receptors; Insulin-like growth factors; Metabolism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Somatomedinas / Receptor de Insulina / Proteínas de Unión a Factor de Crecimiento Similar a la Insulina Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Metab Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

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