Your browser doesn't support javascript.
loading
Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis.
Park, Sangbum; Matte-Martone, Catherine; Gonzalez, David G; Lathrop, Elizabeth A; May, Dennis P; Pineda, Cristiana M; Moore, Jessica L; Boucher, Jonathan D; Marsh, Edward; Schmitter-Sánchez, Axel; Cockburn, Katie; Markova, Olga; Bellaïche, Yohanns; Greco, Valentina.
Afiliación
  • Park S; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Matte-Martone C; Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA.
  • Gonzalez DG; Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
  • Lathrop EA; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
  • May DP; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Pineda CM; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Moore JL; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Boucher JD; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Marsh E; School of Medicine, Georgetown University, Washington, DC, USA.
  • Schmitter-Sánchez A; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Cockburn K; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Markova O; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
  • Bellaïche Y; Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA.
  • Greco V; Cell and Molecular Biology Program, College of Natural Science, Michigan State University, East Lansing, MI, USA.
Nat Cell Biol ; 23(5): 476-484, 2021 05.
Article en En | MEDLINE | ID: mdl-33958758
Organs consist of multiple cell types that ensure proper architecture and function. How different cell types coexist and interact to maintain their homeostasis in vivo remains elusive. The skin epidermis comprises mostly epithelial cells, but also harbours Langerhans cells (LCs) and dendritic epidermal T cells (DETCs). Whether and how distributions of LCs and DETCs are regulated during homeostasis is unclear. Here, by tracking individual cells in the skin of live adult mice over time, we show that LCs and DETCs actively maintain a non-random spatial distribution despite continuous turnover of neighbouring basal epithelial cells. Moreover, the density of epithelial cells regulates the composition of LCs and DETCs in the epidermis. Finally, LCs require the GTPase Rac1 to maintain their positional stability, density and tiling pattern reminiscent of neuronal self-avoidance. We propose that these cellular mechanisms provide the epidermis with an optimal response to environmental insults.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Linfocitos T / Epidermis / Células Epidérmicas Límite: Animals Idioma: En Revista: Nat Cell Biol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Linfocitos T / Epidermis / Células Epidérmicas Límite: Animals Idioma: En Revista: Nat Cell Biol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido