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Iron induces two distinct Ca2+ signalling cascades in astrocytes.
Guan, Wenzheng; Xia, Maosheng; Ji, Ming; Chen, Beina; Li, Shuai; Zhang, Manman; Liang, Shanshan; Chen, Binjie; Gong, Wenliang; Dong, Chengyi; Wen, Gehua; Zhan, Xiaoni; Zhang, Dianjun; Li, Xinyu; Zhou, Yuefei; Guan, Dawei; Verkhratsky, Alexei; Li, Baoman.
Afiliación
  • Guan W; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Xia M; The First Department of Reproduction, Shengjing Hospital, China Medical University, Shenyang, China.
  • Ji M; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Chen B; Department of Orthopaedics, The First Hospital, China Medical University, Shenyang, PR China.
  • Li S; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Zhang M; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
  • Liang S; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Chen B; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
  • Gong W; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Dong C; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
  • Wen G; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Zhan X; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
  • Zhang D; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Li X; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
  • Zhou Y; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Guan D; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
  • Verkhratsky A; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, PR China.
  • Li B; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
Commun Biol ; 4(1): 525, 2021 05 05.
Article en En | MEDLINE | ID: mdl-33953326
Iron is the fundamental element for numerous physiological functions. Plasmalemmal divalent metal ion transporter 1 (DMT1) is responsible for cellular uptake of ferrous (Fe2+), whereas transferrin receptors (TFR) carry transferrin (TF)-bound ferric (Fe3+). In this study we performed detailed analysis of the action of Fe ions on cytoplasmic free calcium ion concentration ([Ca2+]i) in astrocytes. Administration of Fe2+ or Fe3+ in µM concentrations evoked [Ca2+]i in astrocytes in vitro and in vivo. Iron ions trigger increase in [Ca2+]i through two distinct molecular cascades. Uptake of Fe2+ by DMT1 inhibits astroglial Na+-K+-ATPase, which leads to elevation in cytoplasmic Na+ concentration, thus reversing Na+/Ca2+ exchanger and thereby generating Ca2+ influx. Uptake of Fe3+ by TF-TFR stimulates phospholipase C to produce inositol 1,4,5-trisphosphate (InsP3), thus triggering InsP3 receptor-mediated Ca2+ release from endoplasmic reticulum. In summary, these findings reveal the mechanisms of iron-induced astrocytic signalling operational in conditions of iron overload.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Transferrina / Compuestos Férricos / Compuestos Ferrosos / Astrocitos / Calcio / Señalización del Calcio / Proteínas de Transporte de Catión Límite: Animals Idioma: En Revista: Commun Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Transferrina / Compuestos Férricos / Compuestos Ferrosos / Astrocitos / Calcio / Señalización del Calcio / Proteínas de Transporte de Catión Límite: Animals Idioma: En Revista: Commun Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido