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Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells.
Lepperød, Mikkel Elle; Christensen, Ane Charlotte; Lensjø, Kristian Kinden; Buccino, Alessio Paolo; Yu, Jai; Fyhn, Marianne; Hafting, Torkel.
Afiliación
  • Lepperød ME; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Christensen AC; Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway.
  • Lensjø KK; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Buccino AP; Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway.
  • Yu J; Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway.
  • Fyhn M; Department of Biosciences, University of Oslo, Oslo, Norway.
  • Hafting T; Centre for Integrative Neuroplasticity, University of Oslo, Oslo, Norway.
Sci Adv ; 7(19)2021 05.
Article en En | MEDLINE | ID: mdl-33952512
Grid cells in the medial entorhinal cortex (MEC) exhibit remarkable spatial activity patterns with spikes coordinated by theta oscillations driven by the medial septal area (MSA). Spikes from grid cells progress relative to the theta phase in a phenomenon called phase precession, which is suggested as essential to create the spatial periodicity of grid cells. Here, we show that optogenetic activation of parvalbumin-positive (PV+) cells in the MSA enabled selective pacing of local field potential (LFP) oscillations in MEC. During optogenetic stimulation, the grid cells were locked to the imposed pacing frequency but kept their spatial patterns. Phase precession was abolished, and speed information was no longer reflected in the LFP oscillations but was still carried by rate coding of individual MEC neurons. Together, these results support that theta oscillations are not critical to the spatial pattern of grid cells and do not carry a crucial velocity signal.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos