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Sex differences in gut microbiota modulation of aversive conditioning, open field activity, and basolateral amygdala dendritic spine density.
Geary, Caroline Grace; Wilk, Victoria Christina; Barton, Katherine Louise; Jefferson, Parvaneh Ottavia; Binder, Tea; Bhutani, Vasvi; Baker, Claire Luisa; Fernando-Peiris, Achal James; Mousley, Alexa Lee; Rozental, Stefano Freitas Andrade; Thompson, Hannah Mae; Touchon, Justin Charles; Esteban, David Justin; Bergstrom, Hadley Creighton.
Afiliación
  • Geary CG; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Wilk VC; Department of Biology, Vassar College, Poughkeepsie, NY, USA.
  • Barton KL; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Jefferson PO; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Binder T; Department of Biology, Vassar College, Poughkeepsie, NY, USA.
  • Bhutani V; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Baker CL; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Fernando-Peiris AJ; Department of Biology, Vassar College, Poughkeepsie, NY, USA.
  • Mousley AL; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Rozental SFA; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Thompson HM; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
  • Touchon JC; Department of Biology, Vassar College, Poughkeepsie, NY, USA.
  • Esteban DJ; Department of Biology, Vassar College, Poughkeepsie, NY, USA.
  • Bergstrom HC; Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie, NY, USA.
J Neurosci Res ; 99(7): 1780-1801, 2021 07.
Article en En | MEDLINE | ID: mdl-33951219
Gut microbiota influence numerous aspects of host biology, including brain structure and function. Growing evidence implicates gut microbiota in aversive conditioning and anxiety-related behaviors, but research has focused almost exclusively on males. To investigate whether effects of gut dysbiosis on aversive learning and memory differ by sex, adult female and male C57BL/6N mice were orally administered a moderate dose of nonabsorbable antimicrobial medications (ATMs: neomycin, bacitracin, and pimaricin) or a control over 10 days. Changes in gut microbiome composition were analyzed by 16S rRNA sequencing. Open field behavior, cued aversive learning, context recall, and cued recall were assessed. Following behavioral testing, the morphology of basolateral amygdala (BLA) principal neuron dendrites and spines was characterized. Results revealed that ATMs induced gut dysbiosis in both sexes, with stronger effects in females. ATMs also exerted sex-specific effects on behavior and neuroanatomy. Males were more susceptible than females to microbial modulation of locomotor activity and anxiety-like behavior. Females were more susceptible than males to ATM-induced impairments in aversive learning and cued recall. Context recall remained intact, as did dendritic structure of BLA principal neurons. However, ATMs exerted a sex-specific effect on spine density. A second experiment was conducted to isolate the effects of gut perturbation to cued recall. Extinction was also examined. Results revealed no effect of ATMs on cued recall or extinction, suggesting that gut dysbiosis preferentially impacts aversive learning. These data shed new light on how gut microbiota interact with sex to influence aversive conditioning, open field behavior, and BLA dendritic spine architecture.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Caracteres Sexuales / Disbiosis / Complejo Nuclear Basolateral / Eje Cerebro-Intestino Límite: Animals Idioma: En Revista: J Neurosci Res Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Caracteres Sexuales / Disbiosis / Complejo Nuclear Basolateral / Eje Cerebro-Intestino Límite: Animals Idioma: En Revista: J Neurosci Res Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos