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A flow cytometric assay to detect platelet-activating antibodies in VITT after ChAdOx1 nCov-19 vaccination.
Handtke, Stefan; Wolff, Martina; Zaninetti, Carlo; Wesche, Jan; Schönborn, Linda; Aurich, Konstanze; Ulm, Lena; Hübner, Nils-Olaf; Becker, Karsten; Thiele, Thomas; Greinacher, Andreas.
Afiliación
  • Handtke S; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
  • Wolff M; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
  • Zaninetti C; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
  • Wesche J; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
  • Schönborn L; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
  • Aurich K; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
  • Ulm L; Friedrich Loeffler-Institute of Medical Microbiology, and.
  • Hübner NO; Central Unit for Infection Prevention and Control, University Medicine Greifswald, Greifswald, Germany.
  • Becker K; Friedrich Loeffler-Institute of Medical Microbiology, and.
  • Thiele T; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
  • Greinacher A; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine.
Blood ; 137(26): 3656-3659, 2021 07 01.
Article en En | MEDLINE | ID: mdl-33945605
Vaccination is crucial in combatting the severe acute respiratory syndrome coronavirus 2 pandemic. The rare complication of thrombocytopenia and thrombotic complications at unusual sites after ChAdOx1 nCov-19 vaccination is caused by platelet-activating antibodies directed against platelet factor 4 (PF4). We present a widely applicable whole-blood standard flow cytometric assay to identify the pathogenic antibodies associated with vaccine-induced immune-mediated thrombotic thrombocytopenia (VITT) after ChAdOx1 nCov-19 vaccination. This assay will enable rapid diagnosis by many laboratories. This trial was registered at www.clinicaltrials.gov as #NCT04370119.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Inmunoglobulina G / Factor Plaquetario 4 / Activación Plaquetaria / Vacunación / Púrpura Trombocitopénica Idiopática / Receptores de IgG / Citometría de Flujo / Vacunas contra la COVID-19 / SARS-CoV-2 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Blood Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Inmunoglobulina G / Factor Plaquetario 4 / Activación Plaquetaria / Vacunación / Púrpura Trombocitopénica Idiopática / Receptores de IgG / Citometría de Flujo / Vacunas contra la COVID-19 / SARS-CoV-2 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Blood Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos