Your browser doesn't support javascript.
loading
Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences.
Moradi Chameh, Homeira; Rich, Scott; Wang, Lihua; Chen, Fu-Der; Zhang, Liang; Carlen, Peter L; Tripathy, Shreejoy J; Valiante, Taufik A.
Afiliación
  • Moradi Chameh H; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
  • Rich S; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
  • Wang L; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
  • Chen FD; Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.
  • Zhang L; Max Planck Institute of Microstructure Physics, Halle, Germany.
  • Carlen PL; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
  • Tripathy SJ; Departments of Medicine & Physiology, University of Toronto, Toronto, ON, Canada.
  • Valiante TA; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Nat Commun ; 12(1): 2497, 2021 05 03.
Article en En | MEDLINE | ID: mdl-33941783
In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To characterize this potential distinctiveness, we use in vitro whole-cell recordings from cortical layers 2 and 3 (L2&3), layer 3c (L3c) and layer 5 (L5) of the human cortex. Across all layers we observe notable heterogeneity, indicating human cortical pyramidal neurons are an electrophysiologically diverse population. L5 pyramidal cells are the most excitable of these neurons and exhibit the most prominent sag current (abolished by blockade of the hyperpolarization activated cation current, Ih). While subthreshold resonance is more common in L3c and L5, we rarely observe this resonance at frequencies greater than 2 Hz. However, the frequency dependent gain of L5 neurons reveals they are most adept at tracking both delta and theta frequency inputs, a unique feature that may indirectly be important for the generation of cortical theta oscillations.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales de Acción / Células Piramidales / Neocórtex / Fenómenos Electrofisiológicos / Ondas Encefálicas Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales de Acción / Células Piramidales / Neocórtex / Fenómenos Electrofisiológicos / Ondas Encefálicas Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido