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[Impact of positive surgical margins on prostate cancer prognosis]. / Impact carcinologique des marges positives après prostatectomie totale.
Tambwe Kayombo, R; Léon, P; Lasserre, T; Fournier, R; Branchu, B; Hulin, M; Durlach, A; Larré, S.
Afiliación
  • Tambwe Kayombo R; Service d'urologie, CHU de Reims, 51100 Reims, France. Electronic address: rickytambwe@gmail.com.
  • Léon P; Service d'urologie, Clinique Pasteur, 17200 Royan, France.
  • Lasserre T; Service d'Urologie, CMC Les Cèdres, 19100 Brive, France.
  • Fournier R; Service d'Urologie, Centre d'Urologie Trénel, 69560 Sainte-Colombe, France.
  • Branchu B; Service d'urologie, CHU de Reims, 51100 Reims, France.
  • Hulin M; Service d'urologie, CHU de Reims, 51100 Reims, France.
  • Durlach A; Laboratoire d'anatomopathologie, CHU de Reims, 51100 Reims, France.
  • Larré S; Service d'urologie, CHU de Reims, 51100 Reims, France.
Prog Urol ; 31(12): 709-715, 2021 Oct.
Article en Fr | MEDLINE | ID: mdl-33941458
OBJECTIVE: To examine the impact of positive surgical margins (PSM) after radical prostatectomy (RP) for prostate cancer on oncological results. PATIENTS AND METHODS: We performed a study where all patients who underwent radical prostatectomy between January 2004 and December 2018 for prostate cancer were included. The preoperative, postoperative data and the carcinological results collected were analyzed. Data were analysed using Kaplan-Meier survival analysis and proportional hazards models. RESULTS: A total of 319 patients with a median age of 65 years (IQR : 62-69) were included. The median follow-up was 43.6 months (IQR: 19.4-79.3). The overall rate of PSM was 33.5%. PSM was associated with biochemical recurrence (P<0.001). Overall mortality was not associated with positive margins. A clinical stage> T1c was an independent predictor of PSM on multivariate analysis (P=0.01). CONCLUSION: PSM would increase the risk of biochemical recurrence with no impact on survival. Clinical stage>T1c was an adverse predictor for PSM. LEVEL OF EVIDENCE: 3.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Márgenes de Escisión Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male / Middle aged Idioma: Fr Revista: Prog Urol Asunto de la revista: UROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Márgenes de Escisión Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male / Middle aged Idioma: Fr Revista: Prog Urol Asunto de la revista: UROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Francia