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Whole-genome sequencing analysis of semi-supercentenarians.
Garagnani, Paolo; Marquis, Julien; Delledonne, Massimo; Pirazzini, Chiara; Marasco, Elena; Kwiatkowska, Katarzyna Malgorzata; Iannuzzi, Vincenzo; Bacalini, Maria Giulia; Valsesia, Armand; Carayol, Jerome; Raymond, Frederic; Ferrarini, Alberto; Xumerle, Luciano; Collino, Sebastiano; Mari, Daniela; Arosio, Beatrice; Casati, Martina; Ferri, Evelyn; Monti, Daniela; Nacmias, Benedetta; Sorbi, Sandro; Luiselli, Donata; Pettener, Davide; Castellani, Gastone; Sala, Claudia; Passarino, Giuseppe; De Rango, Francesco; D'Aquila, Patrizia; Bertamini, Luca; Martinelli, Nicola; Girelli, Domenico; Olivieri, Oliviero; Giuliani, Cristina; Descombes, Patrick; Franceschi, Claudio.
Afiliación
  • Garagnani P; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
  • Marquis J; Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden.
  • Delledonne M; Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, Bologna, Italy.
  • Pirazzini C; Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
  • Marasco E; Functional Genomics Laboratory, Department of Biotechnology, University of Verona, Verona, Italy.
  • Kwiatkowska KM; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Iannuzzi V; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
  • Bacalini MG; Applied Biomedical Research Center (CRBA), S. Orsola-Malpighi Polyclinic, Bologna, Italy.
  • Valsesia A; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
  • Carayol J; Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate), University of Bologna, Bologna, Italy.
  • Raymond F; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Ferrarini A; Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
  • Xumerle L; Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
  • Collino S; Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
  • Mari D; Functional Genomics Laboratory, Department of Biotechnology, University of Verona, Verona, Italy.
  • Arosio B; Functional Genomics Laboratory, Department of Biotechnology, University of Verona, Verona, Italy.
  • Casati M; Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
  • Ferri E; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
  • Monti D; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
  • Nacmias B; Geriatric Unit, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
  • Sorbi S; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
  • Luiselli D; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
  • Pettener D; Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Castellani G; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
  • Sala C; IRCCS Fondazione Don Carlo Gnocchi, Firenze, Italy.
  • Passarino G; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
  • De Rango F; IRCCS Fondazione Don Carlo Gnocchi, Firenze, Italy.
  • D'Aquila P; Department for the Cultural Heritage (DBC), University of Bologna, Ravenna, Italy.
  • Bertamini L; Department of Biological, Geological, and Environmental Sciences (BiGeA), Laboratory of Molecular Anthropology and Centre for Genome Biology, University of Bologna, Bologna, Italy.
  • Martinelli N; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
  • Girelli D; Department of Physics and Astronomy, University of Bologna, Bologna, Italy.
  • Olivieri O; Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
  • Giuliani C; Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
  • Descombes P; Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
  • Franceschi C; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Elife ; 102021 05 04.
Article en En | MEDLINE | ID: mdl-33941312
Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme decades of human life avoided or largely postponed all major age-related diseases. In this study, we sequenced at high coverage (90X) the whole genome of 81 semi-supercentenarians and supercentenarians [105+/110+] (mean age: 106.6 ± 1.6) and of 36 healthy unrelated geographically matched controls (mean age 68.0 ± 5.9) recruited in Italy. The results showed that 105+/110+ are characterized by a peculiar genetic background associated with efficient DNA repair mechanisms, as evidenced by both germline data (common and rare variants) and somatic mutations patterns (lower mutation load if compared to younger healthy controls). Results were replicated in a second independent cohort of 333 Italian centenarians and 358 geographically matched controls. The genetics of 105+/110+ identified DNA repair and clonal haematopoiesis as crucial players for healthy aging and for the protection from cardiovascular events.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reparación del ADN / Secuenciación Completa del Genoma / Hematopoyesis Clonal / Longevidad Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reparación del ADN / Secuenciación Completa del Genoma / Hematopoyesis Clonal / Longevidad Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido