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Serum and urine free light chains measurements in patients with systemic sclerosis: novel biomarkers for disease activity.
Gigante, Antonietta; Pellicano, Chiara; Leodori, Giorgia; Napodano, Cecilia; Vantaggio, Lorenzo; Gulli, Francesca; Marino, Mariapaola; Visentini, Marcella; Rosato, Edoardo; Basile, Umberto.
Afiliación
  • Gigante A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
  • Pellicano C; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
  • Leodori G; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
  • Napodano C; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.
  • Vantaggio L; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
  • Gulli F; Laboratorio di Patologia Clinica, Ospedale Madre Giuseppina Vannini, Rome, Italy.
  • Marino M; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.
  • Visentini M; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
  • Rosato E; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
  • Basile U; Area Diagnostica di Laboratorio, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario 'A. Gemelli', IRCCS, Rome, Italy.
Clin Exp Immunol ; 205(2): 135-141, 2021 08.
Article en En | MEDLINE | ID: mdl-33934349
Circulating free light chains (FLCs), considered biomarkers of B cell activity, are frequently elevated in patients affected by systemic inflammatory autoimmune diseases. As the systemic sclerosis (SSc) clinical course can be variable, this study is aimed at evaluating FLCs levels in affected individuals as biomarkers of disease activity. We assessed FLC levels in serum and urine of 72 SSc patients and 30 healthy controls (HC). Results were analyzed in comparison with overall clinical and laboratory findings, disease activity index (DAI) and disease severity scale (DSS). SSc patients displayed increased levels of κ and λ FLC in serum significantly higher than HC (p = 0.0001) alongside the mean values of free κ/λ ratio and κ + λ sum (p = 0.0001). SSc patients showed increased free κ in urine with a κ/λ higher than HC (p = 0.0001). SSc patients with increased κ + λ in serum showed that erythro-sedimentation rate (p = 0.034), C-reactive protein (p = 0.003), DAI (p = 0.024) and DSS (p = 0.015) were higher if compared to SSc patients with normal levels of FLC. A positive linear correlation was found between serum levels of free κ and DAI (r = 0.29, p = 0.014). In addition, SSc patients with increased free κ in urine had higher DAI (p = 0.048) than SSc patients with normal κ levels. Our results strengthen the role of serum FLC as useful biomarker in clinical practice to early diagnosis and monitor disease activity, showing for the first time that also urine FLC levels correlated with disease activity in SSc patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Biomarcadores / Cadenas Ligeras de Inmunoglobulina Tipo de estudio: Screening_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerodermia Sistémica / Biomarcadores / Cadenas Ligeras de Inmunoglobulina Tipo de estudio: Screening_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido