Antipsychotic clozapine binding to alpha-2-macroglobulin protects interacting partners against oxidation and preserves the anti-proteinase activity of the protein.

Sunderic, Milos; Vasovic, Tamara; Milcic, Milos; Miljevic, Cedo; Nedic, Olgica; Nikolic, Milan R; Gligorijevic, Nikola

Sunderic, Milos; Vasovic, Tamara; Milcic, Milos; Miljevic, Cedo; Nedic, Olgica; Nikolic, Milan R; Gligorijevic, Nikola.

Afiliación

Sunderic M; Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia. Electronic address: milos@inep.co.rs.
Vasovic T; Department of Biochemistry, Center of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Milcic M; Department of Biochemistry, Center of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Miljevic C; Institute of Mental Health, University of Belgrade - Faculty of Medicine, Milana Kasanina 3, 11000 Belgrade, Serbia.
Nedic O; Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Nikolic MR; Department of Biochemistry, Center of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Gligorijevic N; Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.

Int J Biol Macromol ; 183: 502-512, 2021 Jul 31.

Article en En | MEDLINE | ID: mdl-33930446

Asunto(s)

Antipsicóticos/metabolismo; Clozapina/metabolismo; Estrés Oxidativo; alfa-Macroglobulinas/metabolismo; Antipsicóticos/química; Sitios de Unión; Clozapina/química; Humanos; Enlace de Hidrógeno; Interacciones Hidrofóbicas e Hidrofílicas; Simulación del Acoplamiento Molecular; Oxidación-Reducción; Unión Proteica; Conformación Proteica; Relación Estructura-Actividad; alfa-Macroglobulinas/química

Palabras clave

Alpha-2-macroglobulin; Clozapine; Protein-ligand interaction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Alfa-Macroglobulinas / Clozapina / Estrés Oxidativo Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos

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