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Lasius fuliginosus Nest Carton as a Source of New Promising Bioactive Extracts with Chemopreventive Potential.
Wagner, Grzegorz Karol; Jaszek, Magdalena; Staniec, Bernard; Prendecka, Monika; Pigon, Dominika; Belcarz, Anna; Stefaniuk, Dawid; Matuszewska, Anna; Pietrykowska-Tudruj, Ewa; Zagaja, Miroslaw.
Afiliación
  • Wagner GK; Department of Zoology and Nature Protection, Institute of Biological Sciences, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
  • Jaszek M; Department of Biochemistry and Biotechnology, Institute of Biological Sciences, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
  • Staniec B; Department of Zoology and Nature Protection, Institute of Biological Sciences, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
  • Prendecka M; Chair and Department of Human Physiology, Medical University of Lublin, Radziwillowska 11, 20-080 Lublin, Poland.
  • Pigon D; Chair and Department of Human Physiology, Medical University of Lublin, Radziwillowska 11, 20-080 Lublin, Poland.
  • Belcarz A; Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland.
  • Stefaniuk D; Department of Biochemistry and Biotechnology, Institute of Biological Sciences, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
  • Matuszewska A; Department of Biochemistry and Biotechnology, Institute of Biological Sciences, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
  • Pietrykowska-Tudruj E; Department of Zoology and Nature Protection, Institute of Biological Sciences, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
  • Zagaja M; Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland.
Int J Mol Sci ; 22(9)2021 Apr 22.
Article en En | MEDLINE | ID: mdl-33922345
Six new water extracts (E1-E6) were obtained from nest carton produced by jet black ants Lasius fuliginosus and tested for their biochemical and bioactive properties, including antioxidative and anticancer effects. The present study demonstrated significant qualitative and quantitative differences in the content of individual biochemical constituents, as well as bioactive properties between the investigated samples. All tested extracts demonstrated antioxidant properties (determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods), and the highest antioxidative potential was recorded in extracts E1 and E2 (188.96 and 313.67 µg/mL of ascorbic acid equivalent for ABTS and 176.42 and 202.66 µg/mL for DPPH reagent). Furthermore the six extracts exhibited strong inhibitory activity towards human melanoma cells of the A-375 CRL-1619 line in a dose-dependent manner. The most interesting chemopreventive activity was exhibited by extract E2, which inhibited the proliferation of A-375 cells to the greatest extent, while having a minimal effect on Vero cells. The effect on cancer cells has been confirmed using the Electric Cell-substrate Impedance Sensing (ECIS) technique. Significant impedance changes have been detected in A-375 and Vero cells following the administration of extract E2. The obtained results are really promising and constitute the basis for further research on the nest carton of jet black ant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormigas / Neoplasias Cutáneas / Extractos de Tejidos / Melanoma / Antineoplásicos / Antioxidantes Tipo de estudio: Qualitative_research Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormigas / Neoplasias Cutáneas / Extractos de Tejidos / Melanoma / Antineoplásicos / Antioxidantes Tipo de estudio: Qualitative_research Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza