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Oral Microbiota Changes in Elderly Patients, an Indicator of Alzheimer's Disease.
Wu, Yi-Fan; Lee, Wei-Fang; Salamanca, Eisner; Yao, Wan-Ling; Su, Jo-Ning; Wang, Sin-Yu; Hu, Chaur-Jong; Chang, Wei-Jen.
Afiliación
  • Wu YF; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Lee WF; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Salamanca E; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Yao WL; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Su JN; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Wang SY; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Hu CJ; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Chang WJ; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Int J Environ Res Public Health ; 18(8)2021 04 15.
Article en En | MEDLINE | ID: mdl-33921182
Alzheimer's disease (AD) is a neurodegenerative disease that usually affects older individuals. Owing to the higher incidence of root caries and missing teeth in elderly individuals, the bacteria involved in these dental concerns might potentially deteriorate their cognitive function. Altered microbiota in the oral cavity may induce neuroinflammation through migration from the oral cavity to the brain. However, the correlation between the composition of the oral microbiota and neurodegenerative disease remains unclear. In this study, we evaluated sequence to determine the relative abundance and diversity of bacterial taxa in the dental plaque of elderly patients with AD and controls. Oral samples; the DMFT index; and other clinical examination data were collected from 17 patients with AD and 18 normal elderly individuals as the control group. Patients with AD had significantly more missing teeth and higher dental plaque weight but lower microbial diversity than controls. Significantly increased numbers of Lactobacillales, Streptococcaceae, and Firmicutes/Bacteroidetes and a significantly decreased number of Fusobacterium were observed in patients with AD. In conclusion, using the PacBio single-molecule real-time (SMRT) sequencing platform to survey the microbiota dysbiosis biomarkers in the oral cavity of elderly individuals could serve as a tool to identify patients with AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Caries Dental / Enfermedad de Alzheimer / Microbiota Límite: Aged / Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Caries Dental / Enfermedad de Alzheimer / Microbiota Límite: Aged / Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza