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Tumor-Associated Macrophages-Implications for Molecular Oncology and Imaging.
Kimm, Melanie A; Klenk, Christopher; Alunni-Fabbroni, Marianna; Kästle, Sophia; Stechele, Matthias; Ricke, Jens; Eisenblätter, Michel; Wildgruber, Moritz.
Afiliación
  • Kimm MA; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
  • Klenk C; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
  • Alunni-Fabbroni M; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
  • Kästle S; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
  • Stechele M; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
  • Ricke J; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
  • Eisenblätter M; Department of Diagnostic and Interventional Radiology, Freiburg University Hospital, 79106 Freiburg, Germany.
  • Wildgruber M; Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedicines ; 9(4)2021 Apr 02.
Article en En | MEDLINE | ID: mdl-33918295
Tumor-associated macrophages (TAMs) represent the largest group of leukocytes within the tumor microenvironment (TME) of solid tumors and orchestrate the composition of anti- as well as pro-tumorigenic factors. This makes TAMs an excellent target for novel cancer therapies. The plasticity of TAMs resulting in varying membrane receptors and expression of intracellular proteins allow the specific characterization of different subsets of TAMs. Those markers similarly allow tracking of TAMs by different means of molecular imaging. This review aims to provides an overview of the origin of tumor-associated macrophages, their polarization in different subtypes, and how characteristic markers of the subtypes can be used as targets for molecular imaging and theranostic approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza