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Murine Double Minute 2 Gene (MDM2) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women.
Shebli, Weam Talal Yehya; Alotibi, Mohammad Kdaimes H; Al-Raddadi, Rawya Ibrahim; Al-Amri, Razan Jamaan; Fallatah, Emad Ibrahim Yagoub; Alhujaily, Ahmed Safar; Mohamed, Hiba Salaheldin.
Afiliación
  • Shebli WTY; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia.
  • Alotibi MKH; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia.
  • Al-Raddadi RI; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia.
  • Al-Amri RJ; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia.
  • Fallatah EIY; Department of Oncology, King Fahad Hospital, Madinah, Saudi Arabia.
  • Alhujaily AS; Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia.
  • Mohamed HS; Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia.
Saudi J Biol Sci ; 28(4): 2272-2277, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33911942
Breast cancer is predominant causes of mortality in women worldwide. Genetic polymorphisms have a significant role in breast cancer aetiology. TP53 and its inhibitor the murine double minute 2 (MDM2) genes encode proteins that have crucial functions in the DNA damage response. The allelic variations within these genes could influence the susceptibility to breast cancer. MDM2 promotor polymorphism rs937283A/G has a role in susceptibility to cancer and modifies the promoter activity. In the present case-control study, the association of MDM2 rs937283A/G polymorphism and breast cancer susceptibility in Saudi women with samples of 137 breast cancer patients, and 98 healthy controls were explored. MDM2 gene polymorphism rs937283A/G was genotyped by polymerase chain reaction restriction fragment length polymorphism and confirmed by sequencing. The results revealed that rs937283A/G variant is significantly increases the risk of breast cancer in Saudi women (p-value = 0.0078). Moreover, rs937283A/G polymorphism was associated with high risk of breast cancer in estrogen positive breast cancer patients (p-value = 0.0088), progesterone positive breast cancer patients (p-value = 0.0043), human epidermal growth factor receptor 2 negative breast cancer patients (p-value = 0.0026), and triple negative breast cancer patients where (p-value = 0.0003). Positive association between increased breast cancer risk and rs937283 variant in premenopausal Saudi women, below 50 years of age, was demonstrated (p-value = 0.0023). Collectively, MDM2 rs937283A/G polymorphism could act as a possible biomarker for breast cancer susceptibility in Saudi women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Saudi J Biol Sci Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Arabia Saudita
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Saudi J Biol Sci Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Arabia Saudita