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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
Choe, Joseph H; Watchmaker, Payal B; Simic, Milos S; Gilbert, Ryan D; Li, Aileen W; Krasnow, Nira A; Downey, Kira M; Yu, Wei; Carrera, Diego A; Celli, Anna; Cho, Juhyun; Briones, Jessica D; Duecker, Jason M; Goretsky, Yitzhar E; Dannenfelser, Ruth; Cardarelli, Lia; Troyanskaya, Olga; Sidhu, Sachdev S; Roybal, Kole T; Okada, Hideho; Lim, Wendell A.
Afiliación
  • Choe JH; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Watchmaker PB; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Simic MS; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Gilbert RD; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Li AW; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Krasnow NA; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Downey KM; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Yu W; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Carrera DA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Celli A; Department of Veterans' Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Cho J; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Briones JD; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Duecker JM; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Goretsky YE; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Dannenfelser R; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.
  • Cardarelli L; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA.
  • Troyanskaya O; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Sidhu SS; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  • Roybal KT; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.
  • Okada H; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA.
  • Lim WA; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Sci Transl Med ; 13(591)2021 04 28.
Article en En | MEDLINE | ID: mdl-33910979
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos