Your browser doesn't support javascript.
loading
Bioinspired mineral-polymeric hybrid hyaluronic acid/poly (γ-glutamic acid) hydrogels as tunable scaffolds for stem cells differentiation.
Liu, Shuai; Li, Peili; Liu, Xin; Wang, Penghui; Xue, Wenliang; Ren, Yanhan; Yang, Rong; Chi, Bo; Ye, Zhiwen.
Afiliación
  • Liu S; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China; School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
  • Li P; School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
  • Liu X; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China.
  • Wang P; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China.
  • Xue W; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China.
  • Ren Y; Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
  • Yang R; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China.
  • Chi B; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China; Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, 211816, China. Electronic address: chi
  • Ye Z; School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China. Electronic address: yezw@njust.edu.cn.
Carbohydr Polym ; 264: 118048, 2021 Jul 15.
Article en En | MEDLINE | ID: mdl-33910750
Aiming at the difficulty of integrated repair of osteochondral tissue, we designed a hybrid hydrogel scaffold that mimicked the microenvironment of osteochondral niches. Besides, the nano-hydroxyapatite (nHAP) was specially introduced into the hydrogel for its natural ability to promote bone regeneration. The hydrogel also exhibited good toughness (7500 KJ/m3), strength (1000 kPa), viscoelasticity, and in vitro cell experiments showed that hydrogels had quite good cytocompatibility (near 100 % viability). The results of the three-dimensional (3D) cell culture also proved that the survival rate of the cells in the hybrid hydrogels doped with nHAP and dispersion were the highest. In vitro RT-qPCR experiments proved that after being cultured in hydrogel scaffolds doped with nHAP, bone mesenchymal stem cells (BMSCs) could express genes related to osteoblasts and chondrocytes. As a result, this hydrogel provides a general for developing alternative materials applicable for stem cells differentiation and even osteochondral tissue engineering.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglutámico / Diferenciación Celular / Hidrogeles / Andamios del Tejido / Células Madre Mesenquimatosas / Ácido Hialurónico Límite: Humans Idioma: En Revista: Carbohydr Polym Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglutámico / Diferenciación Celular / Hidrogeles / Andamios del Tejido / Células Madre Mesenquimatosas / Ácido Hialurónico Límite: Humans Idioma: En Revista: Carbohydr Polym Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido