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Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey.
Celen Yuceturk, Selma; Aydogan Turkoglu, Sumeyye; Kockar, Feray; Kucukbay, F Zehra; Azaz, A Dilek.
Afiliación
  • Celen Yuceturk S; Department of Molecular Biology and Genetics, Faculty of Science and Literature, Balikesir University, 10145Balikesir, Turkey.
  • Aydogan Turkoglu S; Department of Molecular Biology and Genetics, Faculty of Science and Literature, Balikesir University, 10145Balikesir, Turkey.
  • Kockar F; Department of Molecular Biology and Genetics, Faculty of Science and Literature, Balikesir University, 10145Balikesir, Turkey.
  • Kucukbay FZ; Department of Basic Pharmaceutical Sciences, Division of Analytical Chemistry, Faculty of Pharmacy, Inönü University, 44280Malatya, Turkey.
  • Azaz AD; Department of Biology, Faculty of Science and Literature, Balikesir University, 10145Balikesir, Turkey.
Z Naturforsch C J Biosci ; 76(5-6): 193-203, 2021 May 26.
Article en En | MEDLINE | ID: mdl-33909957
In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using hydrodistillation method, analyzed by gas chromatography/mass spectrometry (GC-MS), and 66 compounds were identified. The main component was determined as camphor at 16.6%. The antioxidant properties were identified with the DPPH (2,2'-diphenyl-1-picrylhydrazyl) radical-scavenging method and, 33.39 ± 0.25% DPPH was scavenging in 1000 µg/mL of essential oil. The strong antimicrobial activity was observed against Escherichia coli, Enterobacter aerogenes, Proteus vulgaris, and Pseudomonas aeruginosa with MIC values of 125 µg/mL. Aspergillus flavus was more sensitive (28%) against T. convolutus essential oil than other fungi. The cytotoxic effect of oil was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Camphor was effective on human hepatoma cells (Hep3B) at concentrations of 1 mg/mL, 500, 250, and 125 µg/mL, while essential oil of T. convolutus was found to be effective at concentrations of 250 and 125 µg/mL. A reduction in cell proliferation was observed in colon carcinoma cells (HT-29) treated with 500 µg/mL camphor for 48 h. No statistically significant effect was found in Umbilical Vein Endothelial Cells (HUVEC) treated with essential oil and camphor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites Volátiles / Thymus (Planta) / Antiinfecciosos / Antineoplásicos Fitogénicos / Antioxidantes Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Z Naturforsch C J Biosci Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites Volátiles / Thymus (Planta) / Antiinfecciosos / Antineoplásicos Fitogénicos / Antioxidantes Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Z Naturforsch C J Biosci Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania