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Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants.
Zhu, Mei; Zhou, Huiyu; Ma, Ling; Dong, Biao; Zhou, Jinming; Zhang, Guoning; Wang, Minghua; Wang, Juxian; Cen, Shan; Wang, Yucheng.
Afiliación
  • Zhu M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
  • Zhou H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
  • Ma L; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
  • Dong B; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
  • Zhou J; Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua, 321004, China.
  • Zhang G; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
  • Wang M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
  • Wang J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. Electronic address: imbjxwang@163.com.
  • Cen S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. Electronic address: shancen@imb.pumc.edu.cn.
  • Wang Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. Electronic address: wangyucheng@imb.pumc.edu.cn.
Eur J Med Chem ; 220: 113450, 2021 Aug 05.
Article en En | MEDLINE | ID: mdl-33906049
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Diseño de Fármacos / Proteasa del VIH / VIH-1 / Inhibidores de la Proteasa del VIH / Fármacos Anti-VIH Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Diseño de Fármacos / Proteasa del VIH / VIH-1 / Inhibidores de la Proteasa del VIH / Fármacos Anti-VIH Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia