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Deletion of Dcf1 Reduces Amyloid-ß Aggregation and Mitigates Memory Deficits.
Li, Wei-Hao; Gan, Lin-Hua; Ma, Fang-Fang; Feng, Rui-Li; Wang, Jiao; Li, Yan-Hui; Sun, Yang-Yang; Wang, Ya-Jiang; Diao, Xin; Qian, Fei-Yang; Wen, Tie-Qiao.
Afiliación
  • Li WH; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Gan LH; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Ma FF; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Feng RL; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Wang J; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Li YH; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Sun YY; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Wang YJ; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Diao X; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Qian FY; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
  • Wen TQ; Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China.
J Alzheimers Dis ; 81(3): 1181-1194, 2021.
Article en En | MEDLINE | ID: mdl-33896839
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease. One of the pathologies of AD is the accumulation of amyloid-ß (Aß) to form senile plaques, leading to a decline in cognitive ability and a lack of learning and memory. However, the cause leading to Aß aggregation is not well understood. Dendritic cell factor 1 (Dcf1) shows a high expression in the entorhinal cortex neurons and neurofibrillary tangles in AD patients. OBJECTIVE: Our goal is to investigate the effect of Dcf1 on Aß aggregation and memory deficits in AD development. METHODS: The mouse and Drosophila AD model were used to test the expression and aggregation of Aß, senile plaque formation, and pathological changes in cognitive behavior during dcf1 knockout and expression. We finally explored possible drug target effects through intracerebroventricular delivery of Dcf1 antibodies. RESULTS: Deletion of Dcf1 resulted in decreased Aß42 level and deposition, and rescued AMPA Receptor (GluA2) levels in the hippocampus of APP-PS1-AD mice. In Aß42 AD Drosophila, the expression of Dcf1 in Aß42 AD flies aggravated the formation and accumulation of senile plaques, significantly reduced its climbing ability and learning-memory. Data analysis from all 20 donors with and without AD patients aged between 80 and 90 indicated a high-level expression of Dcf1 in the temporal neocortex. Dcf1 contributed to Aß aggregation by UV spectroscopy assay. Intracerebroventricular delivery of Dcf1 antibodies in the hippocampus reduced the area of senile plaques and reversed learning and memory deficits in APP-PS1-AD mice. CONCLUSION: Dcf1 causes Aß-plaque accumulation, inhibiting dcf1 expression could potentially offer therapeutic avenues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Agregación Patológica de Proteínas / Hipocampo / Proteínas de la Membrana / Trastornos de la Memoria / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies Límite: Aged80 / Animals / Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Agregación Patológica de Proteínas / Hipocampo / Proteínas de la Membrana / Trastornos de la Memoria / Proteínas del Tejido Nervioso Tipo de estudio: Prognostic_studies Límite: Aged80 / Animals / Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos