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Trypsinogen and chymotrypsinogen: potent anti-tumor agents.
González-Titos, Aitor; Hernández-Camarero, Pablo; Barungi, Shivan; Marchal, Juan Antonio; Kenyon, Julian; Perán, Macarena.
Afiliación
  • González-Titos A; Department of Health Sciences, University of Jaén, Jaén, Spain.
  • Hernández-Camarero P; Department of Health Sciences, University of Jaén, Jaén, Spain.
  • Barungi S; Department of Health Sciences, University of Jaén, Jaén, Spain.
  • Marchal JA; Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain.
  • Kenyon J; Biosanitary Research Institute of Granada (Ibs. GRANADA), University Hospitals of Granada-University of Granada, Granada, Spain.
  • Perán M; Excellence Research Unit "Modeling Nature" (Mnat), University of Granada, Granada, Spain.
Expert Opin Biol Ther ; 21(12): 1609-1621, 2021 12.
Article en En | MEDLINE | ID: mdl-33896307
Introduction: Trypsinogen and chymotrypsinogen have been used clinically in tissue repair due to their ability to resolve inflammatory symptoms. Recently, novel evidence has supported the anti-tumourigenic potential of a mixture of trypsinogen and chymotrypsinogen.Areas covered: First, we analyze the structure of these proteases and the effects of pancreatic proteinases on tissue repair, inflammation and the immune system. Second, we summarize studies that provided evidence of the effects of pancreatic (pro)enzymes on tumor cells both in vitro and in vivo and some successful clinical applications of pancreatic (pro)enzymes. Finally, we study pancreatic (pro)enzymes potential molecular targets, such as the proteinase-activated receptors (PARs).Expert opinion: This novel therapy has been shown to have effective antitumor effects. Treatment with these (pro) enzymes sensitizes Cancer Stem Cells (CSCs) which may allow chemotherapy and radiotherapy to be more effective, which could positively affect the recovery of cancer patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tripsinógeno / Neoplasias Límite: Humans Idioma: En Revista: Expert Opin Biol Ther Asunto de la revista: BIOLOGIA / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tripsinógeno / Neoplasias Límite: Humans Idioma: En Revista: Expert Opin Biol Ther Asunto de la revista: BIOLOGIA / TERAPEUTICA Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido