Autoradiographic analysis of hepatocytes in mirex-induced adaptive liver growth.
Am J Physiol
; 255(1 Pt 1): G132-9, 1988 Jul.
Article
en En
| MEDLINE
| ID: mdl-3389413
The relationships between [3H]thymidine incorporation into hepatocyte nuclei, cell enlargement, and mitotic index were studied in intact (INT) and adrenalectomized (ADX) mirex-dosed rats. In INT mirex-dosed rats the sequence of events included the following: a biphasic response in nuclear labeling of mononuclear hepatocytes with peaks at 48 and 66 h postmirex dose, a peak in mitotic activity 66 h postmirex dose, and a significant increase in binuclear hepatocyte size 48 h postmirex dose. In ADX mirex-dosed rats the sequence of events included the following: a biphasic response in nuclear labeling of mononuclear hepatocytes with peaks at 24 and 48 h postmirex dose, a peak in mitotic activity 60 h postmirex dose, and a marginal increase in binuclear hepatocyte size 48 h postmirex dose. Corticosterone supplements to ADX mirex-dosed rats significantly reduced nuclear labeling of the mononuclear hepatocytes and increased the size of binuclear hepatocytes to that observed in INT mirex-dosed rats. This study demonstrates that adaptive liver growth consists of a hyperplastic response that involves mononuclear hepatocytes and a hypertrophic response that involves binuclear hepatocytes. Both responses appear to be modulated by corticosterone.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Insecticidas
/
Hígado
/
Mírex
Límite:
Animals
Idioma:
En
Revista:
Am J Physiol
Año:
1988
Tipo del documento:
Article
Pais de publicación:
Estados Unidos