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40-Hz auditory stimulation for intracranial interictal activity: A pilot study.
Quon, Robert J; Leslie, Grace A; Camp, Edward J; Meisenhelter, Stephen; Steimel, Sarah A; Song, Yinchen; Ettinger, Alan B; Bujarski, Krzysztof A; Casey, Michael A; Jobst, Barbara C.
Afiliación
  • Quon RJ; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Leslie GA; Department of Music, Georgia Institute of Technology, Atlanta, GA, USA.
  • Camp EJ; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • Meisenhelter S; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • Steimel SA; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Song Y; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Ettinger AB; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • Bujarski KA; United Diagnostics, New Hyde Park, NY, USA.
  • Casey MA; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • Jobst BC; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Acta Neurol Scand ; 144(2): 192-201, 2021 Aug.
Article en En | MEDLINE | ID: mdl-33893999
OBJECTIVES: To study the effects of auditory stimuli on interictal epileptiform discharge (IED) rates evident with intracranial monitoring. MATERIALS AND METHODS: Eight subjects undergoing intracranial EEG monitoring for refractory epilepsy participated in this study. Auditory stimuli consisted of a 40-Hz tone, a 440-Hz tone modulated by a 40-Hz sinusoid, Mozart's Sonata for Two Pianos in D Major (K448), and K448 modulated by a 40-Hz sinusoid (modK448). Subjects were stratified into high- and low-IED rate groups defined by baseline IED rates. Subject-level analyses identified individual responses to auditory stimuli, discerned specific brain regions with significant reductions in IED rates, and examined the influence auditory stimuli had on whole-brain sigma power (12-16 Hz). RESULTS: All subjects in the high baseline IED group had a significant 35.25% average reduction in IEDs during the 40-Hz tone; subject-level reductions localized to mesial and lateral temporal regions. Exposure to Mozart K448 showed significant yet less homogeneous responses. A post hoc analysis demonstrated two of the four subjects with positive IED responses had increased whole-brain power at the sigma frequency band during 40-Hz stimulation. CONCLUSIONS: Our study is the first to evaluate the relationship between 40-Hz auditory stimulation and IED rates in refractory epilepsy. We reveal that 40-Hz auditory stimuli may be a noninvasive adjunctive intervention to reduce IED burden. Our pilot study supports the future examination of 40-Hz auditory stimuli in a larger population of subjects with high baseline IED rates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Acústica / Encéfalo / Electrocorticografía Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurol Scand Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Acústica / Encéfalo / Electrocorticografía Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurol Scand Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca