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Experimental Evaluation of Anxiolytic and Analgesic Properties of a New Linear Methoxyphenyltriazaalkane Derivative with Cardiotropic Activity.
Kolik, L G; Nadorova, A V; Tsorin, I B; Barchukov, V V; Mokrov, G V; Likhosherstov, A M; Gudasheva, T A; Kryzhanovskii, S A; Durnev, A D.
Afiliación
  • Kolik LG; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. lgkolik@mail.ru.
  • Nadorova AV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Tsorin IB; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Barchukov VV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Mokrov GV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Likhosherstov AM; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Gudasheva TA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Kryzhanovskii SA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Durnev AD; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Bull Exp Biol Med ; 170(6): 763-768, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33893960
The anxiolytic and analgesic properties of compound ALM-802, a cardiotropic linear methoxyphenyltriazaalkane derivative, combining pharmacophore elements of p-FOX inhibitors trimetazidine and ranolazine were studied in vivo. In the elevated plus-maze test, ALM-802 after acute intraperitoneal administration in doses of 1-8 mg/kg dose-dependently prevented the development of anxiety in BALB/c mice. Chronic intraperitoneal administration of ALM-802 in a dose of 2 mg/kg to alcohol-preferring rats attenuated anxiogenesis induced by ethanol withdrawal. ALM-802 demonstrated antinociceptive activity in C57BL/6 mice during thermal stimulation of nociceptors in the hot plate test and during modeling of visceral pain in the acetic acid writhing test. Thus, ALM-802 exhibits anxiolytic and analgesic properties in the dose range corresponding to its anti-ischemic and antiarrhythmic effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trimetazidina / Nocicepción Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trimetazidina / Nocicepción Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos