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Applying limiting entropy to quantify the alignment of collagen fibers by polarized light imaging.
Qu, Yingjie; Smith, Zachary J; Tyler, Kelly; Chang, Shufang; Shen, Shuwei; Sun, Mingzhai; Xu, Ronald X.
Afiliación
  • Qu Y; Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China.
  • Smith ZJ; Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China.
  • Tyler K; Department of Dermatology, the Ohio State University, Columbus, USA.
  • Chang S; Department of Obstetrics and Gynecology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Shen S; Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China.
  • Sun M; Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China.
  • Xu RX; Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China.
Math Biosci Eng ; 18(3): 2331-2356, 2021 03 08.
Article en En | MEDLINE | ID: mdl-33892548
Collagen alignment has shown clinical significance in a variety of diseases. For instance, vulvar lichen sclerosus (VLS) is characterized by homogenization of collagen fibers with increasing risk of malignant transformation. To date, a variety of imaging techniques have been developed to visualize collagen fibers. However, few works focused on quantifying the alignment quality of collagen fiber. To assess the level of disorder of local fiber orientation, the homogeneity index (HI) based on limiting entropy is proposed as an indicator of disorder. Our proposed methods are validated by verification experiments on Poly Lactic Acid (PLA) filament phantoms with controlled alignment quality of fibers. A case study on 20 VLS tissue biopsies and 14 normal tissue biopsies shows that HI can effectively characterize VLS tissue from normal tissue (P < 0.01). The classification results are very promising with a sensitivity of 93% and a specificity of 95%, which indicated that our method can provide quantitative assessment for the alignment quality of collagen fibers in VLS tissue and aid in improving histopathological examination of VLS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colágeno / Matriz Extracelular Tipo de estudio: Diagnostic_studies Idioma: En Revista: Math Biosci Eng Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colágeno / Matriz Extracelular Tipo de estudio: Diagnostic_studies Idioma: En Revista: Math Biosci Eng Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos